DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	562	Identity:	135/562 - (24%)
Similarity:	236/562 - (41%)	Gaps:	94/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GDFGPFQ--KRLLF----WMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELE-------GLPESE 68
            |..|.||  :.|.|    .|:|:..|.      :.|...:| .|.|....|:       .:....
Human    11 GGVGLFQTLQVLTFILPCLMIPSQMLL------ENFSAAIP-GHRCWTHMLDNGSAVSTNMTPKA 68

  Fly    69 QKNRGIPKKQDGSFENCFMYNVP----YDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEY 129
            .....||...:.....|..:..|    .|.|||..:.......||.:||:||| .|...:|..::
Human    69 LLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDR-SVFTSTIVAKW 132

  Fly   130 NWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSM---IGGCVSVVCKDFP 191
            :.||..:.....|..::..|.:||...:|.::...||.|.|   :.|.:   :.|..::....|.
Human   133 DLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPML---SWCCLQLAVAGTSTIFAPTFV 194

  Fly   192 CFAASRFVAGLSMNYCFVPIYILTLENVGIKYR----TLVGNLALTFFFTLGACLLPWLAYVISN 252
            .:...||||...|...|:....|.:|......|    |:||     ..|:.|...|..||:.:.:
Human   195 IYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVG-----CAFSAGQAALGGLAFALRD 254

  Fly   253 WRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANG-----KIISEEVWSE 312
            ||...:..::|...:.|.|...|||..||:..||.|:.::.:::.|:.||     .:..|.:.|.
Human   255 WRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSS 319

  Fly   313 MRECYELKFANEQLGKQYTSLDLF-------KTFPRLVVLTILIVTWMTVALAYDAHVRVVEILD 370
            ::|  |:..|.|    ..:.||||       ::...|||...|::::  ..|.:|     ::.|.
Human   320 VKE--EVASAKE----PRSVLDLFCVPVLRWRSCAMLVVNFSLLISY--YGLVFD-----LQSLG 371

  Fly   371 TDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSL---------------FVGI 420
            .|||:..:|...|:........|||..:||:.:.:....:...:.|               |..:
Human   372 RDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVL 436

  Fly   421 LKGHWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRY 485
            .||.:..|...:..             :.:|:.||.:|.....|::.:|::||::.||:|.:.:.
Human   437 GKGCFGISLTCLTI-------------YKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQA 488

  Fly   486 YRPLPMFIITLVSVIGALIIL-FLPETKGATMPQTLDEAEKR 526
            ...||..:..::|:..:|::| |||||:|..:|.|:.:.|.:
Human   489 LPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQ 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	133/553 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	94/402 (23%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	133/553 (24%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550		135/562 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950