DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a13b

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_017209322.1	Gene:	slc22a13b / 556601	ZFINID:	ZDB-GENE-061013-532	Length:	549	Species:	Danio rerio

Alignment Length:	559	Identity:	154/559 - (27%)
Similarity:	260/559 - (46%)	Gaps:	47/559 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIF-MILLPKNHWCR----VRELEGLPESE 68
            :...|..:|:||.||||||..:.......||..|||:| .|..|  |:|.    :|:...|.|.:
Zfish     4 FTQILSSVGEFGAFQKRLLVAVCLPNIFTAFHMFGQVFTAISFP--HYCNSSWILRQAPNLTEEK 66

  Fly    69 QKNRGIPKKQDGSFENCFMYNVPYDSNATN----DANQTRSPIPCNNGWIYDRKEVPYES--IAT 127
            |.|..:|....|.:|:|.|: .|.:.:..:    ..|.|.|   |.:||:|   :.|.:|  :.|
Zfish    67 QLNLTVPLDSKGQYESCKMF-TPVEMDIEDIEHYGINTTTS---CIDGWVY---KAPKDSSTLIT 124

  Fly   128 EYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPC 192
            |::.||:.:.:...|..:|..|.:||.|.||.:.|..||..|..|:.....:.|.......:...
Zfish   125 EFDLVCENKVYSEASQSIYMAGLLVGALLFGPMADKYGRRFATLLSLFLQFLSGVGVAFSPNIYV 189

  Fly   193 FAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYA 257
            :.|.|||.|.:::...:..::|..|..|...|.|...|: ..||.:|..||..:||.|.|||...
Zfish   190 YIALRFVVGTTISGISINTFVLGTEWCGSAKRALFTILS-HCFFAIGLMLLSGVAYGIRNWRVLQ 253

  Fly   258 MVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFA 322
            :|::.|:....:...:.|||..||::.||:|.....:.:||:.||:.:||.:..:|..
Zfish   254 LVLSAPVGLFFIYYWILPESARWLLTQGKLDSAKREILKAARINGRKVSENLLDKMEA------- 311

  Fly   323 NEQLGKQYTSLDLFKT-FPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIP 386
             |...|..|.:|||:. :.|...| |:...|...:|.|......|.....||::|..:..:.|.|
Zfish   312 -ENTAKSSTMIDLFRVGYLRKRAL-IMCYMWFVTSLVYYGVSLNVGNFGLDIYLTQLIFGMAEFP 374

  Fly   387 AGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWN--ASTAAIAARFFATMAYNVGQQWA 449
            |.:....|:.|.||:...|.|:||...:.|.:..:...:.  .:..|:..:|....::::...:.
Zfish   375 ARLSCFPLIQRFGRRICQSVVLLLGGTACLIIPAIPAKYPIVVTVIAVIGKFSLAASFSIVYVYT 439

  Fly   450 SEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKG- 513
            :|:.|||:|..|:.:.::..::..:|:||:.....|:..:||.|...:..:|..:...||||..
Zfish   440 AELYPTVVRQNGVGLNSMCARVAGILAPLIGLLDVYHHAIPMIIYGSLPFVGGALTFLLPETLNT 504

  Fly   514 ---------ATMPQTLDEAE-KRWTLR---CRDRKINED 539
                     |....|:.|.: :||..|   .|:|..::|
Zfish   505 DLQDHTDIPADESMTVTEVKLERWGRRRGWDRERSTSQD 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	145/525 (28%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	97/370 (26%)
slc22a13b	XP_017209322.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850