DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and slc22a23

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001338637.1	Gene:	slc22a23 / 555979	ZFINID:	ZDB-GENE-030131-3564	Length:	942	Species:	Danio rerio

Alignment Length:	553	Identity:	133/553 - (24%)
Similarity:	233/553 - (42%)	Gaps:	89/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKRL--LFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRGIPKKQ 78
            :|.||.:||:|  |.| :||.|: .|:.|...|::..|    |        ||....:..:....
Zfish    45 VGGFGKYQKQLIVLTW-IPAIFI-GFSQFSDNFLLTNP----C--------PEPHNNSSQLLTVA 95

  Fly    79 DGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCD---KRDFGT 140
            ..:....|   ...::.|.:..|.|.|.....||.        .::|.|::|.|||   |.....
Zfish    96 PTAVSTVF---TGVNTEAASQCNCTPSSYKLQNGL--------EQNIVTKWNLVCDSAWKIHIAK 149

  Fly   141 YSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMN 205
            :|::   ||.|.|.|..|.:.|..||.|.|.|:....::.|.......:.|.|...||..|..:.
Zfish   150 FSLL---VGSIFGYLVLGVLADWFGRHPVLILSVVFLLVFGMTVAFSVNLPMFGTLRFFEGFCLA 211

  Fly   206 YCFVPIYILTLENVGIKYR---TLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFM 267
            ...:.:|:|.:|.....:|   |:|.|    |....|..|:|.||.:..:|:....|:..|::.|
Zfish   212 GITLSLYVLRIELCLPGWRFSITMVAN----FMMLAGQLLMPGLAALCRDWQILQAVIVCPLLLM 272

  Fly   268 ILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKII---SEEVWSEMRECYELKFANEQLGKQ 329
            :......|||..||::..:..|...:|:..:|.|...:   :||:.:|:....:.:.....:.|.
Zfish   273 LSYIWAFPESLRWLLATQQYSRSKWIMERISKKNNINLQEDAEELMTELNGALQKQPKKTCIVKM 337

  Fly   330 YTSLDLFKTFPRLVVLTILIVTWMTVALAYDAH------------VRVVEILDTDIFITFSLSSL 382
            ..:.:|:|   .:|||.:..:|      .|..|            |..||.|. |.:..:.:.::
Zfish   338 VGTRNLWK---NIVVLCVNSLT------GYGIHHCFARSMMEKKTVGFVEKLH-DFYAEYYVMAV 392

  Fly   383 VEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLF-VGILK--GHWN---------------AST 429
            :.:.:.:.....:..:||:..:...|::.|.:||. :|:|.  |.:.               :..
Zfish   393 IAVASCVFLCPAVALMGRRGGLLMFMIITALASLLQLGLLNLLGKYGDHLSLVHSDELNDKFSVA 457

  Fly   430 AAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHR---YYRPLPM 491
            .:|...|.:....|:...:.:||.|:|:||.||.::......|.|.|| ::..|.   |:  |..
Zfish   458 FSIIGMFSSHAVSNLSIFFCAEITPSVIRGGGLGLVLASAGFGMLTSP-IMELHNQKGYF--LHH 519

  Fly   492 FIITLVSVIGALIILFLPETKGATMPQTLDEAE 524
            .|....::|..:.||.||||:...:|:||.:.|
Zfish   520 IIFACCTLICIICILLLPETRNQPLPETLSDGE 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	130/545 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	93/406 (23%)
slc22a23	NP_001338637.1	Sugar_tr	<131..547	CDD:331684	105/435 (24%)
slc22a23	NP_001338637.1	Atrophin-1	630..>937	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.030