DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Orct2

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	142/539 - (26%)
Similarity:	264/539 - (48%)	Gaps:	37/539 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEG----LPESEQ 69
            |:..::.:||||.:||.:.|.:...:...||.....:|::..| :..|.:....|    || :..
  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKP-DFRCALPFENGSSYDLP-THL 65

  Fly    70 KNRGIPKKQDGSFENCFMYNVPYDSNATN-----DANQTRSPIPCNNGWIYDRKEVPYESIATEY 129
            .|...|:.     |.|..|:|.|.....|     .:|:|::   |:: ::|||.:. ..|..||:
  Fly    66 WNLSYPEN-----ERCSYYDVDYTEEYLNGSIPRSSNETKT---CSS-YVYDRSKY-LNSAVTEW 120

  Fly   130 NWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFA 194
            |.||.:......|..::.:|.::|.:.||.::|..||.|.||.:....::.|.::.|..::..:.
  Fly   121 NLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYT 185

  Fly   195 ASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMV 259
            .:|.:.|.:.:..|:..|::.:|.||...|...| :.:..||::|..|....||.:.:||...:.
  Fly   186 FARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAG-IFVMMFFSVGFMLTAVFAYFVHDWRWLQIA 249

  Fly   260 VALP-IVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEM-------REC 316
            :.|| ::||....:: |||..||:..|:.|..|..|::||:.|...||:|..||:       .|.
  Fly   250 LTLPGLIFMFYYWII-PESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEK 313

  Fly   317 YELKFANEQL--GKQYTSLDLFKTFPRLVVLTILI-VTWMTVALAYDAHVRVVEILDTDIFITFS 378
            .:.|..:::|  |...:..||| .:|.|...|:|| :.|:..:..|.........|..::.:.|.
  Fly   314 AKQKLEDQELDEGPPPSVWDLF-CYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFV 377

  Fly   379 LSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL--KGHWNASTAAIAARFFATMA 441
            :|..|||||.|..:|.|:|.||:.::...:::...|.|...|:  :.|......|:..:...|.:
  Fly   378 ISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITAS 442

  Fly   442 YNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIIL 506
            |.....:::|..|||:|...|...:::.::..:::|.:......::|||:.|...::::..|:.|
  Fly   443 YGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSL 507

  Fly   507 FLPETKGATMPQTLDEAEK 525
            .||||....|.:|:.:.|:
  Fly   508 LLPETHNKPMLETIADGER 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	139/523 (27%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	99/380 (26%)
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	139/523 (27%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	97/378 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.890