DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and CG16727

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	183/536 - (34%)
Similarity:	281/536 - (52%)	Gaps:	42/536 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73
            ::..|...|:||.||..:|........|.:..||.|..:...|: |||...:|.||..:|.::
  Fly     3 FDRVLEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPE-HWCSHDDLMGLGAAELRS-- 64

  Fly    74 IPKKQDGSFENCFMY-NVPYDS--------NATNDANQTRSPIPCNNGWIYDRKEVPYESIATEY 129
                         :| ||.:.|        |.|..|::.    .|.: ||::| |..|||:.||.
  Fly    65 -------------IYSNVSHPSCTLLSEVINGTGVASEE----SCQD-WIFER-ENGYESLTTEL 110

  Fly   130 NWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFA 194
            .|||||..........:|:|.:||.:.|||::||.|||||:.:|......|..::......|.||
  Fly   111 KWVCDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLPWFA 175

  Fly   195 ASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMV 259
            .||||:|||.:..:..:|||..|.:..|.||...|:.|..|:..|....||:|..|.|||.|..:
  Fly   176 FSRFVSGLSTDTMYYLMYILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYLWL 240

  Fly   260 VALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANE 324
            .:||.:.:::..||..||..||::..|.|..:..:|:.||.||:.:.:.|:.|..:.|..|...|
  Fly   241 ASLPALGVLIYPLLICESAQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEFVKHYREKMNEE 305

  Fly   325 -QLGKQY-TSLDLFKTFPRL-VVLTILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIP 386
             :|.||. |.|.:||| ||| ...|.|:|..:.:.|:||...|.:|.|.:..|..|||:|.|.:|
  Fly   306 SKLNKQMDTFLGMFKT-PRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFSLTSSVYLP 369

  Fly   387 AGIVPMLLLDRIGRKPMMSAVML----LCAASSLFVGILKGHWNASTAAI---AARFFATMAYNV 444
            ||...:||.::||||.|....:|    :.|.:...:.:|....||...|:   ..||..|::|:.
  Fly   370 AGFTILLLQNKIGRKGMACGALLVGAIITAVTGFLIAVLDPSENAVLLALMVGLGRFGTTVSYDA 434

  Fly   445 GQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLP 509
            ..|:|:||:||.:|||.::.|:::|...:.|:..|:...:||:|||...|:::..:|||:.|.||
  Fly   435 EIQYAAEIIPTSVRGQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISVLMFLGALLCLTLP 499

  Fly   510 ETKGATMPQTLDEAEK 525
            ||....:|:||.:.|:
  Fly   500 ETLHKKLPETLADGER 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	179/520 (34%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	134/377 (36%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	179/520 (34%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	134/374 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	7.010