DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	559	Identity:	134/559 - (23%)
Similarity:	244/559 - (43%)	Gaps:	44/559 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQ-KRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVR---ELEGLPESEQ 69
            :.:.|..:|..|.|| ..:....||...:.:.... |.|:..:|.:| |:..   .:......:.
Zfish     3 FSDLLEQVGSTGRFQVLHVTLLSMPILMMASHNLL-QNFVAAVPPHH-CQPHANLSMSSTDAMDV 65

  Fly    70 KNRGIPKKQDGSFENCFMYNVP-------------YDSNATNDANQTRSPIPCNNGWIYDRKEVP 121
            ....:|...:|..|.|..|..|             :|.:......|:     |.:||.|:..|:.
Zfish    66 LRATVPLGLNGKLERCKRYTTPQWQILSLNTSESLWDESMAETETQS-----CEDGWFYNMTEMS 125

  Fly   122 YESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVV 186
             .:|.||::.|||.|.....|...|..|.:||.:.||.::|..||...|.::|....|||.....
Zfish   126 -STIITEWDLVCDYRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIGGTCVAF 189

  Fly   187 CKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVIS 251
            ...|..|...|...|::::...:..:.|.:|.:..:.||:||. ...:.:|.|..:|..:||.|.
Zfish   190 STSFTMFCVFRVCCGMALSGLVLNSFSLIVEWIPTRVRTVVGT-GTGYCYTTGQLILAAVAYCIR 253

  Fly   252 NWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMREC 316
            :||...:.|:||.....|.|....||..||:...|.::.::.:|..|:.||:       |...:.
Zfish   254 DWRWLTLAVSLPFYVSFLYSWWFLESARWLVLTKKPEQAVKNLKTVARINGR-------SAEGDK 311

  Fly   317 YELKFANEQLGKQ-------YTSLDLFKTFPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIF 374
            .:|:...|.:.|:       |::|||.:|.....:...|...|.:.:.||......::.....|:
Zfish   312 IDLEMLQESMKKEMACSKGSYSALDLLRTSTMRTITICLSAVWFSTSFAYYGLSMDLQKFGVSIY 376

  Fly   375 ITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKG---HWNASTAAIAARF 436
            :...:...|:|||.|:..:.:..:||:|.....::| |...:.:.:|..   ....::.|:..:.
Zfish   377 LIQIIFGAVDIPAKIIVTICMSMLGRRPSQCGALVL-AGIMILINLLVPSDLQMLRTSLAVIGKG 440

  Fly   437 FATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIG 501
            ....::|....:|.|:.|||:|..|:..:::|.:.||:::|:||.....|..:|.||.....::.
Zfish   441 CLAASFNCCYLYAGELYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYPWIPGFIYGGAPIVS 505

  Fly   502 ALIILFLPETKGATMPQTLDEAEKRWTLRCRDRKINEDL 540
            .:...|||||....:|.|:.:.:.|...|...:::.|.|
Zfish   506 GIFAFFLPETLSQPLPDTIQDIDDRGLARTNSKRLPEKL 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	128/528 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	92/377 (24%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	128/528 (24%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	103/406 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950