DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a4

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	560	Identity:	149/560 - (26%)
Similarity:	259/560 - (46%)	Gaps:	65/560 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQ----KRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQ 69
            |::...|:|.:||||    ..|...::|..|:..:.    :|:...|. |.|.:.|...: .|..
Zfish     4 YDDITSFLGTWGPFQLTVFLALAISILPNGFVGLYI----VFVGDTPA-HECLIPEQINI-SSVW 62

  Fly    70 KNRGIP-KKQDGSFE--NCFMYNVP---------YDSNATNDANQTRSPIPCNNGWIYDRKEVPY 122
            ::..|| :.|||..:  :|..|.:.         |..|...:.:|..:. ||.:||.|. :|...
Zfish    63 RDAAIPTQMQDGVLKRSSCSRYRLDTLRQLSMLNYTPNVEVNLSQIETE-PCVDGWSYS-QEFYQ 125

  Fly   123 ESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVC 187
            .:|.||::.||::...|..:..:||.|.:||....|.::|..||.|.||...:...|...:.:..
Zfish   126 STIVTEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFS 190

  Fly   188 KDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISN 252
            ..:..|:|..|..|.|....:|..|:|..|.:....|.|.|:|.:.....:|....|..||.|.:
Zfish   191 PSWEVFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAAYFIRS 255

  Fly   253 WRHYAMVVALPIVFMILTSLL-------APESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVW 310
            ||...:..|       ||.||       .||||.||:|.|:......|::.||:.|.....|.::
Zfish   256 WRWLVLTNA-------LTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAPEVIF 313

  Fly   311 SEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIFI 375
            |..    |::.|.::..::::.||:......:..:.|..:.||.:.::|.|.:.....|..:.::
Zfish   314 SSS----EIEEAAKKRIQKHSILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYL 374

  Fly   376 TFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVG------------ILKGHWNAS 428
            .|.||::||:||.|:..|||....|:        :|.||:|.:|            .|:|  .|:
Zfish   375 NFFLSAVVEVPAYIIAALLLRFCSRR--------ICQASTLLLGGALIFIIQLIPTELQG--LAT 429

  Fly   429 TAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFI 493
            ...:..:...|.|:.|.....||:.|||:|...:...::..::|:::||.::....|||.:|..:
Zfish   430 ALEMLGKLCVTAAFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIV 494

  Fly   494 ITLVSVIGALIILFLPETKGATMPQTLDEAEK-RWTLRCR 532
            |..:::...::.|.|||:||..:|:|:.:.:. |...|||
Zfish   495 IGGLALFSGVMSLLLPESKGKVLPETIAQMQSVRGLRRCR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	142/536 (26%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	100/386 (26%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	142/536 (26%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	100/386 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588478
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950