DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A10

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001034841.3	Gene:	SLC22A10 / 387775	HGNCID:	18057	Length:	541	Species:	Homo sapiens

Alignment Length:	568	Identity:	137/568 - (24%)
Similarity:	241/568 - (42%)	Gaps:	87/568 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73
            :|..|..:|..|.||...|.:::|:..|.......:.|...:| .|.|.|..|:       .|.|
Human     3 FEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIP-GHRCWVHMLD-------NNTG 59

  Fly    74 IPKKQDGSFENCFM-YNVPYDSN------------------------ATNDANQTRSPIPCNNGW 113
            ...:.....|:..: .::|.|||                        :|::|:..    ||.:||
Human    60 SGNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTE----PCVDGW 120

  Fly   114 IYDRKEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGR-------LPALF 171
            :||:...| .:|.|:::.|||.:...:....:...|.:||.:..|.::|..||       |..|.
Human   121 VYDQSYFP-STIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCLLQLA 184

  Fly   172 LANSCSMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFF 236
            :.::|       :.....||.:...||:||      |..:.|::..::.|.......:.||....
Human   185 ITDTC-------AAFAPTFPVYCVLRFLAG------FSSMIIISNNSLPITEWIRPNSKALVVIL 236

  Fly   237 TLGA-----CLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKE 296
            :.||     .:|..||||..:|:...:|.::|.....|.|....||..||:...|:|..::.:::
Human   237 SSGALSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALRK 301

  Fly   297 AAKANGKIISEE------VWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLTILIVTWMTV 355
            .|:.||...:||      |.|.|:|  ||..|..:.    |..|||:.......:.||:......
Human   302 VARTNGIKNAEETLNIEVVRSTMQE--ELDAAQTKT----TVCDLFRNPSMRKRICILVFLRFAN 360

  Fly   356 ALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGI 420
            .:.:...:..::.:.::||:...|...|.:....:.:|.|:.:||:......|.|...|.|....
Human   361 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSILANTF 425

  Fly   421 LKGHWNASTAAIA-------ARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPL 478
            :.........|:|       |..|:::|.:.     .|::|||||.:...|.....::||.|:||
Human   426 VPKEMQTLRVALACLGIGCSAATFSSVAVHF-----IELIPTVLRARASGIDLTASRIGAALAPL 485

  Fly   479 VLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKR 526
            :::...::..||..|..:..:||.||:..|||||...:|.|:.:.|.:
Human   486 LMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	133/551 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	93/392 (24%)
SLC22A10	NP_001034841.3	2A0119	11..526	CDD:273328	133/551 (24%)
SLC22A10	NP_001034841.3	MFS	143..516	CDD:119392	93/396 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153704
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940