DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001119757.1	Gene:	Slc22a13 / 316062	RGDID:	1306840	Length:	551	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	157/529 - (29%)
Similarity:	265/529 - (50%)	Gaps:	42/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELE----GLPESEQKNRGIPK 76
            :||||.||.||...|....||.||..|.|:||: |.:.|:|.|..::    .|..:||....||.
  Rat    11 VGDFGRFQVRLTILMGIPNFLSAFFVFSQVFMV-LDEAHYCSVSWVKNHTFNLSAAEQLAVSIPN 74

  Fly    77 KQDGSFENCFMYNVPYDSNATNDA-----NQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCDKR 136
            ...|..|:|.|:..|.|:.:..|.     |:|::   |::||.|.....|  |:..|::.||::.
  Rat    75 DTAGRPESCLMFRPPPDNASLEDILSHRFNETQA---CDSGWDYPENRPP--SLKNEFDLVCERE 134

  Fly   137 DFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFV-- 199
            :....|..|:..|.:||.|.||.:.|..||.|:|.:....|.|....:.....|..:...||.
  Rat   135 NLKRTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQLLLSGIASMATAFVSSFELYMTLRFALA 199

  Fly   200 ---AG--LSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMV 259
               ||  ||.|       :|..|.||...||....||.: .|.||...|..|||.:.|||...::
  Rat   200 TANAGFLLSSN-------VLLSEWVGTSRRTRAMVLAQS-NFALGLMALAGLAYGVRNWRLLQII 256

  Fly   260 VALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANE 324
            ...||..::....:.||||.||:|.|:.:...:::::||..||:.::.|:.:::        ..|
  Rat   257 GTTPIFLLVFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLASELLNQL--------VPE 313

  Fly   325 QLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAG 388
            :.|....:||||: .|:|..:| |||..|...:|.|......|.....||::|..:..:||:||.
  Rat   314 KTGPSGNALDLFR-HPQLRKVTLILIAVWFVDSLLYYGLGFQVGDFGLDIYLTQVIFGVVEVPAR 377

  Fly   389 IVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWN--ASTAAIAARFFATMAYNVGQQWASE 451
            :..:.:::::|||......:.|.....:.:..:.|...  |:..|:..:|.::.|:.:...:.:|
  Rat   378 LSSIPMMEKLGRKWSQLCTLTLAGVMCVIIIFIPGDLPTVATALAVVGKFASSAAFTISYVYTAE 442

  Fly   452 ILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATM 516
            :|||::|..|:.:::|..::|.:::|||:...:|::.:||.|...:.:...|:...||||:|.|:
  Rat   443 LLPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHKAIPMLIFGSLPIGAGLLCALLPETRGQTL 507

  Fly   517 PQTLDEAEK 525
            ..||.:.|:
  Rat   508 KDTLQDLEQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	154/520 (30%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	104/377 (28%)
Slc22a13	NP_001119757.1	2A0119	12..510	CDD:273328	154/520 (30%)
Slc22a13	NP_001119757.1	MFS	139..500	CDD:119392	104/377 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347206
Domainoid	1	1.000	69	1.000	Domainoid score	I9372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950