DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	160/565 - (28%)
Similarity:	252/565 - (44%)	Gaps:	78/565 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RDCEKYENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVREL----EGL 64
            || :|:.:.|..||:||.||.||:......:.|..|......| :|..:..:|....:    ..|
  Rat    47 RD-DKFASVLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHF-LLTAQRPYCNTSWILQVGPNL 109

  Fly    65 PESEQKNRGIPKKQDGSFENCFMY-NVPY--DSNATNDANQTRSPIPCNNGWIYDRKEVPY---E 123
            .|.||.|..:|:..:|||..|.|| .||:  ||......|.|.:   |.:||||     |:   .
  Rat   110 TEDEQLNLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTET---CKHGWIY-----PFAHTR 166

  Fly   124 SIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCK 188
            |:..|::.||...........|:..|.:.|.|.|||::|..||.|.:.|:....:|.|..:....
  Rat   167 SLTNEFDLVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFGTAFVN 231

  Fly   189 DFPCFAASR-FVAGLSMNYCFVPIYILTLENVGIKYRTLVGN------LALTFFFTLGACLLPWL 246
            .|..:...| |||..|:.|...        :|.:....|||.      :....|||:|..||...
  Rat   232 SFYQYLFFRFFVAQASVGYAIC--------SVSLVMEWLVGEHRAQAIILQHCFFTIGVILLTGF 288

  Fly   247 AYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWS 311
            ||.|::||...::..:|:..:|....:..|||.|||..|||:...:|:..||:.|.|.|...:.:
  Rat   289 AYKINHWRLLFLLGGVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNKKTIPLNLLN 353

  Fly   312 EMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLTILIVTWMTVALAYDAHVRVVEILD--TDIF 374
            |::  ...|.|...:...||:..|||     |||.:..| |.||  :|.:....:::.|  .||:
  Rat   354 ELQ--LPGKKAKASILDFYTNQHLFK-----VVLAMGCV-WFTV--SYVSLTLSLKMKDFGLDIY 408

  Fly   375 ITFSLSSLVEIPAGIVPMLLLDRIGRK----PMMSAVMLLCAASSLFVG----------ILKGHW 425
            ....:..:..:||.:..:|||:..|||    ..:|.|...| .|.|||.          ::.|.:
  Rat   409 FIQVVPCITAVPARLCCILLLEYFGRKWSLNLTLSLVTFTC-LSLLFVPEELKSTTILMLVLGEF 472

  Fly   426 N-ASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPL 489
            : |.|.:|   ||.         :.:|:|||:||..||.:::|....||:.|..:....:  ..|
  Rat   473 SMAGTVSI---FFI---------YTAELLPTILRSTGLGMVSIAWTAGAISSLAIFKQTK--TQL 523

  Fly   490 PMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWTLRCRDR 534
            |:|...|..::.......:|||....:..:::.. .|.:|..:|:
  Rat   524 PIFFCCLCCILALCFSSLVPETGNQPLRDSIEYC-SRDSLEHKDK 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	152/535 (28%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	109/391 (28%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	119/420 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9372
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010