DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	138/539 - (25%)
Similarity:	232/539 - (43%)	Gaps:	81/539 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILL----PKNHWCRVRELEGLPESEQKNRGIPK 76
            :|:.|.:|..|.|.:.....|:..|   :..:|.|    |..|| .:.||  ||.....|:...|
  Rat    10 VGEMGLYQMYLCFLLAVLLQLYVAT---EAILIALIGATPAYHW-DMAEL--LPNQSHSNQSSGK 68

  Fly    77 KQDGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCDKRDFGTY 141
            .|  :|.:..:         |.:.::....:..:|.         :.|||:|:..:.::    :|
  Rat    69 GQ--AFGDWLL---------TANGSEIHKHVHFSNS---------FTSIASEWFLIANR----SY 109

  Fly   142 SVVV----YFVGCIVGCLCFGFITDHSGR---------LPALF-LANSCSMIGGCVSVVCKDFPC 192
            .|..    :|.|..||.:.||.::|..||         |..|| :||..|          ..:..
  Rat   110 KVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFS----------PSYEF 164

  Fly   193 FAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYA 257
            ||.:||:.|:......:..::|..|.||..|..|.|::. ..||.:|......|.|.|.:||..|
  Rat   165 FAVTRFLVGMMNGGMSLVAFVLLNECVGAAYWALAGSIG-GLFFAVGIAQYALLGYFIRSWRTLA 228

  Fly   258 MVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMREC-YELKF 321
            ::|.|....:.|.||..||||.||.|.|::....|.:...||.|.|:          :| :.|..
  Rat   229 ILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKL----------KCTFSLTH 283

  Fly   322 -ANEQLGKQYTSLDLFKTFPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEI 385
             ||....:..:.||||:....|....||:..|...:|.|.........|...|:...:||.|:||
  Rat   284 PANRSYRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEI 348

  Fly   386 PAGIVPMLLLDR--IGRKPMMSAVMLLCAASSLFVGIL-----KGHW---NASTAAIAARFFATM 440
            |:..:.:.|:::  .|||..::|.:.|...:.|.|..|     .|.:   |:.:.::..:...:.
  Rat   349 PSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISA 413

  Fly   441 AYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALII 505
            |:|:...:.||:.|||:|..||...::..::|.:::|.|.|.......||..:.....:...|:.
  Rat   414 AFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGATGLTSGLLS 478

  Fly   506 LFLPETKGATMPQTLDEAE 524
            |.||||..:.:.:|..:.:
  Rat   479 LLLPETLNSPLLETFSDLQ 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	137/531 (26%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	107/393 (27%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	104/378 (28%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	99/359 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850