DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	149/529 - (28%)
Similarity:	252/529 - (47%)	Gaps:	20/529 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73
            :.:.|..:|..|.||...:..::....|.|.....|.|...:|.:| ||......|.:.......
  Rat     3 FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHH-CRPPANANLSKDGGLEAW 66

  Fly    74 IPKKQDGSFENCFMYNVP------YDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEYNWV 132
            :|..:.|..|:|..:..|      |  |.| :||.||...||.:||:||....| .:|.||:|.|
  Rat    67 LPLDKQGQPESCLRFTSPQWGPPFY--NGT-EANGTRVTEPCIDGWVYDNSTFP-STIVTEWNLV 127

  Fly   133 CDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASR 197
            |..|.|...:..:|.||.::|.:.||::.|..||...|.|....:.:.|..:....::..:...|
  Rat   128 CSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFR 192

  Fly   198 FVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMVVAL 262
            .::|:|:....:....|.:|.:.|..|..||.| :.:.::||..||..:||.:.:|||..:||::
  Rat   193 LLSGMSLASIAINCMTLNVEWMPIHTRAYVGTL-IGYVYSLGQFLLAGIAYAVPHWRHLQLVVSV 256

  Fly   263 PIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANE-QL 326
            |.....:.|....||..|..|.|::|..:..::..|:.|||  .||......|........| .|
  Rat   257 PFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGK--QEEGAKLSIEVLRTSLQKELTL 319

  Fly   327 GK-QYTSLDLFKTFPRLVVLTI-LIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGI 389
            .| |.::::|.:. |.|..|.: |.:.|...:.||...|..::.....:::...:...|::||..
  Rat   320 SKGQASAMELLRC-PTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKF 383

  Fly   390 VPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL-KGHWNASTA-AIAARFFATMAYNVGQQWASEI 452
            |..|:::.:||:|...|.:||.....|..||: |.|....|: |:..:.....::|....:..|:
  Rat   384 VCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRTSLAVLGKGCLASSFNCIFLYTGEL 448

  Fly   453 LPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATMP 517
            .|||:|..||.:.:.|.::|:::||||..|..:|..:|:||...|.|:.:.:...||||.|..:|
  Rat   449 YPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLP 513

  Fly   518 QTLDEAEKR 526
            .|:.:.:.|
  Rat   514 DTVQDLKSR 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	146/512 (29%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	100/372 (27%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	146/512 (29%)
		MFS	135..505	CDD:119392	100/373 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950