DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	149/544 - (27%)
Similarity:	268/544 - (49%)	Gaps:	45/544 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGL-------PE 66
            ::..|...|:||.||:|:...:......|||.:.|.:|:...|..:|||......|       ||
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    67 SE----QKNRGIPKKQDGSFENCFMYNVPYDSNATND---------ANQTRSPIPCNNGWIYDRK 118
            .|    .....:|.::.|. .:|..|.:. |:|.:::         .|::...:||:..|.|..
  Rat    69 EEWNLTTPELHVPAERRGQ-GHCHRYLLE-DTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVE- 130

  Fly   119 EVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIG--G 181
              .:.:|.::::.||........:..:..:|.:.|....|:..|..|||....:  ||..:|  |
  Rat   131 --THSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLI--SCFGVGITG 191

  Fly   182 CVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWL 246
            .|.....:|..|...||:.|:.....::..:::..|.||.|.|.:|| :.:..|||||..:||.:
  Rat   192 VVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVG-IVIQMFFTLGIIILPGI 255

  Fly   247 AYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWS 311
            ||...:|:...:.::||....:|...:.||||.||::..:.::.:::::..||.|||.:|...
  Rat   256 AYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNY-- 318

  Fly   312 EMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTDIFI 375
                 .|:...:|::... :.|||.:| |::...| ||:..|.|.|:.|...|..:.::..::::
  Rat   319 -----SEITVTDEEVSNP-SCLDLVRT-PQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYM 376

  Fly   376 TFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL-KG-HWNASTAAIAARFFA 438
            .|.:|.|||:|..::.:|.::|:||:...:|..::...|.|....| :| .|..:|.|...|...
  Rat   377 DFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGI 441

  Fly   439 TMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFII-TLVSVIG 501
            |||:.:.....||:.||.||..|:::.:.:...|.:::| |:......:..||:.|. .|.||.|
  Rat   442 TMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCG 506

  Fly   502 ALIILFLPETKGATMPQTLDEAEK 525
            .|::| ||||||..:|:|:::.||
  Rat   507 GLVML-LPETKGIALPETVEDVEK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	145/528 (27%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	105/374 (28%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	145/528 (27%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	105/380 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347440
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850