Protein Alignment CG5592 and Slc22a2

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_113772.1
• Gene: Slc22a2 / 29503
• RGDID: 61936
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 556
• Identity: 164/556 - (29%)
• Similarity: 269/556 - (48%)
• Gaps: 45/556 - (8%)

  Fly    10 ENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNH-W----CRVRELEGLPESEQ 69
            ::.|..||:|..|||:..|.:...:..|...|.|.:|:...|.:| |    .::.:..|..::|:
  Rat     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQAEE 69

  Fly    70 KNRGIP---KKQDGSF-ENCFMYNVPYD----------SNATNDANQTRSPI-PCNNGWIYDRKE 119
            .|..:|   ...:.|| ..|..|.|.::          |:...|.||.  |: ||.:||:|:
  Rat    70 LNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQL--PLGPCEHGWVYN--- 129

  Fly   120 VPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVS 184
            .|..||.||:|.||...........|..||..:|.:..|::.|..||...|.:....:.|.|.:.
  Rat   130 TPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISGALM 194

  Fly   185 VVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYV 249
            .:..::......||:.||.....::..|||..|.||:.||.:|| :.....||:|..:|..:|||
  Rat   195 AISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVG-ICYQIAFTVGLLILAGVAYV 258

  Fly   250 ISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMR 314
            |.|||.....|.||....:|.....||||.||:|..|:.:.::::|..||.|||.:...:
  Rat   259 IPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVSL----- 318

  Fly   315 ECYELKFANEQLGKQY--TSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTDIFIT 376
               :....:|..||:.  :.|||.:| |::...| ||:..|.|.::.|...:..:.:...:|::.
  Rat   319 ---QNLTPDEDAGKKLKPSILDLVRT-PQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLD 379

  Fly   377 FSLSSLVEIPAGIVPMLLLDRIGRK-PMMSAVML---LCAASSLFVGILKGHWNASTAAIAARFF 437
            |..|:|||.||..:.:|.:||:||: |...:.|:   .|.||......|:  |...|.|...|..
  Rat   380 FFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQ--WLKITIACLGRMG 442

  Fly   438 ATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFIITLVSVIG 501
            .||||.:.....:|:.||.:|..|:.:.:.|..:|.:::| ||......:...|:.:..:|.::.
  Rat   443 ITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVA 507

  Fly   502 ALIILFLPETKGATMPQTLDEAEKRWTLRCRDRKIN 537
            ..::|.||||||..:|:|:::||.....|.::||.|
  Rat   508 GALVLLLPETKGKALPETIEDAENMQRPRKKERKEN 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	118/403 (29%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	155/529 (29%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		3/3 (100%)