DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	575	Identity:	136/575 - (23%)
Similarity:	237/575 - (41%)	Gaps:	94/575 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKRLLFW-------MMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73
            :|..|.||..|:.:       :.|...|..||.|        ..:|.|.|..|:....|:.....
Human    10 VGGMGRFQICLIAFFCITNILLFPNIVLENFTAF--------TPSHRCWVPLLDNDTVSDNDTGT 66

  Fly    74 IPKKQDGSFENCFMYNVPYDSNATNDANQ------------------TRSP--IPCNNGWIYDRK 118
            :.|      ::....::|.|||......|                  |..|  .||.:||:|||.
Human    67 LSK------DDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRS 125

  Fly   119 EVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGR-------LPALFLANSC 176
            .. ..:|.||::.||:.:...:....::..|.::|.|.:|.::|..||       ...|.::|:|
Human   126 SF-LSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTC 189

  Fly   177 SMIGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGAC 241
            :.......|.|       ..||:||.|........:||:||....:.|::. .:.|...:::|..
Human   190 AAFAPTFLVYC-------ILRFLAGFSTMTILGNTFILSLEWTLPRSRSMT-IMVLLCSYSVGQM 246

  Fly   242 LLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIIS 306
            ||..||:.|.:|....:.|:.||:.:.|:|....||..||:...::|..::.::..|..|||..:
Human   247 LLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNT 311

  Fly   307 EE------VWSEMRECYELKFANEQLGKQYTSLDLFKTF--PRLVVLTI-LIVTWMTVALAYDAH 362
            ||      |.|.|:         ::|........:|..|  |:|.:... |......:.:.:...
Human   312 EETLTTELVRSTMK---------KELDAVRIKTSIFSLFRAPKLRMRVFGLCFVRFAITVPFYGL 367

  Fly   363 VRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWNA 427
            :..::.|.:::.:...|...|...|..|.:|.|:.:||:   .:.:|......||  ||...:..
Human   368 ILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRR---ISQILFTFPVGLF--ILVNTFLP 427

  Fly   428 STAAIAARFFATM-------AYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRY 485
            ....|.....||:       |.|......:|::||:||.....|..:.|:.||.|:||:::...|
Human   428 QEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAY 492

  Fly   486 YRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWTLRCRDRKINEDL 540
            ...||.....:..::...:||.||||:...:|.|:.:.|       .|||.:.::
Human   493 SPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVE-------NDRKDSRNI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	131/551 (24%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	91/390 (23%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	104/429 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153839
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950