DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	165/555 - (29%)
Similarity:	269/555 - (48%)	Gaps:	54/555 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKR--LLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR---VRELE---GLPESEQKNR 72
            :|:||.|||:  ||..::.|:  .|..|.|.:|:...| .|:|:   |.||.   |..::|:.|.
  Rat    11 VGEFGWFQKQAFLLLCLISAS--LAPIYVGIVFLGFTP-GHYCQNPGVAELSQRCGWSQAEELNY 72

  Fly    73 GIP---KKQDGSF-ENCFMYNVPYDSNATND---------ANQTRSPI-PCNNGWIYDRKEVPYE 123
            .:|   ...:.|| ..|..|.|.: :.:|.|         ||:::.|: ||.:||:||   .|..
  Rat    73 TVPGLGPSDEASFLSQCMRYEVDW-NQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYD---TPGS 133

  Fly   124 SIATEYNWVCDKRDFGTYSVVVYFVGCI-----VGCLCFGFITDHSGRLPALFLANSCSMIGGCV 183
            ||.||:|.||     |....|..|..|:     :|.|..|:|.|..||...|.:....:.:.|.:
  Rat   134 SIVTEFNLVC-----GDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVL 193

  Fly   184 SVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAY 248
            :.|..|:......|.:.|:.....:|..|.|..|.||..||.... :.....||:|...|..:||
  Rat   194 TAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTA-ILYQMAFTVGLVGLAGVAY 257

  Fly   249 VISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEM 313
            .|.:||...:.|:||....:|.....||||.||:|..:..|.:.:|::.|:.|||:...::   .
  Rat   258 AIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPADL---K 319

  Fly   314 RECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTDIFITF 377
            ..|.| :.|:|:....:.  |||:| |.|...| ||:..|.:.|:.|...:..|.....::::.|
  Rat   320 MLCLE-EDASEKRSPSFA--DLFRT-PNLRKHTVILMYLWFSCAVLYQGLIMHVGATGANLYLDF 380

  Fly   378 SLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL--KGHWNASTAAIAARFFATM 440
            ..|||||.||..:.::.:|||||...::|..|:..|:.|.:..:  :.||...|.|...|..||:
  Rat   381 FYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLACLGRMGATI 445

  Fly   441 AYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFIITLVSVIGALI 504
            ...:.....:|:.||.:|..|:.:.:.:..:|.:.:| :|......::.||:.:..::.:....:
  Rat   446 VLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLTAGAM 510

  Fly   505 ILFLPETKGATMPQTLDEAEKRWTLRCRDRKINED 539
            .|.||||||..:|:|::|||   .|..|..|..|:
  Rat   511 TLLLPETKGVALPETIEEAE---NLGRRKSKAKEN 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	157/532 (30%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	102/376 (27%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	157/532 (30%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	115/405 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850