DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and SV2C

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	683	Identity:	126/683 - (18%)
Similarity:	213/683 - (31%)	Gaps:	255/683 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PESEQKN------RGIPKKQDGSFENCFMYNVPYDS-NATNDANQTRSPIPCNNGWIY-DRKEV- 120
            |..|..|      .|..:..:|..|:..:|...|.. .:.|.|..:...:....|..| ||:|:
Human    60 PAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDRRELE 124

  Fly   121 -----PYESIATEYNWVCDKRDFGTYSVVVYFV-------------------------------- 148
                 ..|.:|.:|..:..:...|.:...::||
Human   125 SERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSG 189

  Fly   149 ----------GCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLS 203
                      |.:||...:|.:.|..||..:|.:..|.:.....:|...:.:..|...|.::|..
Human   190 SGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254

  Fly   204 MNYCFVPIY-----ILTLENVGIKYRTLVGNLA-LTFFFTLG---ACLLPWL------------- 246
            :......::     :|..|..|       .:|: |..|:.:|   |..:.|.
Human   255 IGGAIPTVFSYFAEVLAREKRG-------EHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGS 312

  Fly   247 AYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMK----EAAKANG----- 302
            ||...:||.:.:|.|||.|..::.....||||.:|:.|||.|....::|    ...:|.|
Human   313 AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKV 377

  Fly   303 ---------KIISE--EVWSE----MRECYELKFANEQLGKQYTSLDLFKTFP---RLVVLTILI 349
                     |.|.|  |:.|:    .|.|: ::...|..|...|.:..| .:|   ..:.|||:
Human   378 FTVNKIKTPKQIDELIEIESDTGTWYRRCF-VRIRTELYGIWLTFMRCF-NYPVRDNTIKLTIV- 439

  Fly   350 VTWMTVALAY----------------DAHVRVVEILDTDIFITFS-------------------- 378
              |.|::..|                |.:..:...::.|.:..|:
Human   440 --WFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRF 502

  Fly   379 ----------------------------------------------------------------- 378

Human   503 IGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKT 567

  Fly   379 --------------------LSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKG 423
                                |.:|..:|..||..||:|||||..|:...|:|...|..|:
Human   568 GCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFL----- 627

  Fly   424 HWNASTAAIAARFFATMAYN--VGQQWAS------EILPTVLRGQGLAIINIMGQMGALLSPLVL 480
             |..::.::......  .||  ....|.|      |:.||..|..|...:|.:.:..|:|..|:.
Human   628 -WFGTSESMMIGMLC--LYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIF 689

  Fly   481 -STHRYYRPLPMFIITLVSVIGALIILFLPETK 512
             |.....:.:|:.:.:.|.|.|.|:.|.||:|:
Human   690 GSLVSITKSIPILLASTVLVCGGLVGLCLPDTR 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	126/683 (18%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	104/588 (18%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	126/683 (18%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		5/18 (28%)
		MFS	155..719	CDD:119392	104/583 (18%)
		Pentapeptide_3	507..561	CDD:290309	0/53 (0%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		0/43 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910