Protein Alignment CG5592 and SV2C

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_055794.3
• Gene: SV2C / 22987
• HGNCID: 30670
• Length: 727
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 126/683 - (18%)
• Similarity: 213/683 - (31%)
• Gaps: 255/683 - (37%)

  Fly    65 PESEQKN------RGIPKKQDGSFENCFMYNVPYDS-NATNDANQTRSPIPCNNGWIY-DRKEV- 120
            |..|..|      .|..:..:|..|:..:|...|.. .:.|.|..:...:....|..| ||:|:
Human    60 PAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDRRELE 124

  Fly   121 -----PYESIATEYNWVCDKRDFGTYSVVVYFV-------------------------------- 148
                 ..|.:|.:|..:..:...|.:...::||
Human   125 SERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSG 189

  Fly   149 ----------GCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLS 203
                      |.:||...:|.:.|..||..:|.:..|.:.....:|...:.:..|...|.::|..
Human   190 SGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFG 254

  Fly   204 MNYCFVPIY-----ILTLENVGIKYRTLVGNLA-LTFFFTLG---ACLLPWL------------- 246
            :......::     :|..|..|       .:|: |..|:.:|   |..:.|.
Human   255 IGGAIPTVFSYFAEVLAREKRG-------EHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGS 312

  Fly   247 AYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMK----EAAKANG----- 302
            ||...:||.:.:|.|||.|..::.....||||.:|:.|||.|....::|    ...:|.|
Human   313 AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKV 377

  Fly   303 ---------KIISE--EVWSE----MRECYELKFANEQLGKQYTSLDLFKTFP---RLVVLTILI 349
                     |.|.|  |:.|:    .|.|: ::...|..|...|.:..| .:|   ..:.|||:
Human   378 FTVNKIKTPKQIDELIEIESDTGTWYRRCF-VRIRTELYGIWLTFMRCF-NYPVRDNTIKLTIV- 439

  Fly   350 VTWMTVALAY----------------DAHVRVVEILDTDIFITFS-------------------- 378
              |.|::..|                |.:..:...::.|.:..|:
Human   440 --WFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRF 502

  Fly   379 ----------------------------------------------------------------- 378
                                                                             
Human   503 IGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKT 567

  Fly   379 --------------------LSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKG 423
                                |.:|..:|..||..||:|||||..|:...|:|...|..|:
Human   568 GCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFL----- 627

  Fly   424 HWNASTAAIAARFFATMAYN--VGQQWAS------EILPTVLRGQGLAIINIMGQMGALLSPLVL 480
             |..::.::......  .||  ....|.|      |:.||..|..|...:|.:.:..|:|..|:.
Human   628 -WFGTSESMMIGMLC--LYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIF 689

  Fly   481 -STHRYYRPLPMFIITLVSVIGALIILFLPETK 512
             |.....:.:|:.:.:.|.|.|.|:.|.||:|:
Human   690 GSLVSITKSIPILLASTVLVCGGLVGLCLPDTR 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	112/623 (18%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	126/683 (18%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..84		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128		5/18 (28%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781	519..563		0/43 (0%)