DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_036015188.1	Gene:	Slc22a22 / 210463	MGIID:	2446114	Length:	587	Species:	Mus musculus

Alignment Length:	613	Identity:	142/613 - (23%)
Similarity:	250/613 - (40%)	Gaps:	117/613 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVR------ELE---GL 64
            ::..|..:||.|.||..::..:...:.:.:.....:.|...:|.:| |.:.      |:.   .|
Mouse     3 FDEILHHVGDSGRFQICMIILLNILSLVLSPHDVLENFTAAIPAHH-CSINLDNSRSEVSTDMNL 66

  Fly    65 PESEQKNRGIPKKQDGSFENCFMYNVP----YDSNATNDANQTRSPIPCNNGWIYDRKEVPYESI 125
            ...:.....||...:...|.|..:...    .|||.:...:......||.:||.||. .|...:|
Mouse    67 TTEDLMKVSIPMGPNQKPEQCRRFRYTQWQFLDSNISTFNSTELETEPCLDGWTYDH-SVFTSTI 130

  Fly   126 ATE---------------------------------YNWVCDKRDFGTYSVVVYFVGCIVGCLCF 157
            .||                                 ::.|||.:.|..|:......|.:|.|...
Mouse   131 VTEGLSPPQPWDSDQYYHTKHEISPCEEGLKSSVKVWDLVCDFQSFKYYAQATSLAGHLVSCPLS 195

  Fly   158 GFITDHSGRLPALFLANSCSMIGGCVSVVC---KDFPCFAASRFVAGLSMNYCFVPIYILTLENV 219
            |.|:|..||.|.|..   ||:..|.|...|   .:|..:...||:.....:...:...||.||..
Mouse   196 GIISDRFGRKPLLMY---CSLAYGAVGTYCAFAPNFSVYCVLRFLLSAFQSTILINSLILVLEEA 257

  Fly   220 GIKYRTLVGNLALT-FFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMS 283
            .:::...:  :.|: .|.::|..:|..||||||:|....:..|||.....:.....|||..||:.
Mouse   258 SVQWHPTI--IVLSGLFNSIGQGVLGGLAYVISDWHLLQLAYALPFFIFFVLFCWVPESVRWLII 320

  Fly   284 VGKVDRCIEVMKEAAKANGK------IISEEVWSEMRECYELKFANEQLGKQYTSLDLF-KTFPR 341
            .||.|:..:.::..|..|||      :.:|::.|:::     |..| ..||.:...|:| ....|
Mouse   321 TGKTDQAWKELQRIASINGKKGIAQNLTTEDLRSKLK-----KDVN-STGKLFRIKDIFINPLIR 379

  Fly   342 LVVLT----ILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKP 402
            .:||:    :....:..|.|..|     |::|..::|:|......:::|:..:....:..:.|:|
Mouse   380 KIVLSNSSLLFAELFSFVGLLLD-----VQLLGKNMFLTQIFLGAIDVPSKSLTYFTIRNVSRRP 439

  Fly   403 MMSAVMLL---CAASSLFVG-----------IL-KGHWNASTAAIAARFFATMAYNVGQQWASEI 452
            :::.::|.   |...::|:.           || ||.:.|.|.             :...:.:|:
Mouse   440 LIAFLLLTTGSCITITIFISEEMYVLRTIIFILGKGCFAAFTC-------------ISTTYINEL 491

  Fly   453 LPTVLR----GQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKG 513
            .|..||    |..||::.:.|    :||.|.|:|.:|:..|||.:..::.::..:.|||||||..
Mouse   492 SPVELRSTLNGVFLAVVRLAG----VLSALTLATRKYFVYLPMILYGVLPIVATISILFLPETFN 552

  Fly   514 ATMPQTLDEAEKRWTLRCRD--RKINED 539
            ......:.:.|||..|..::  :|..:|
Mouse   553 LPHTDIIKDMEKRKRLMSKNISKKEGQD 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	135/581 (23%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	99/401 (25%)
Slc22a22	XP_036015188.1	MFS_OAT	108..548	CDD:340932	113/473 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940