DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a19

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_659034.1	Gene:	Slc22a19 / 207151	MGIID:	2442751	Length:	551	Species:	Mus musculus

Alignment Length:	565	Identity:	138/565 - (24%)
Similarity:	257/565 - (45%)	Gaps:	81/565 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73
            :::.::.||..|.||...:.:::....|.|.....:.|...:| :|.|.|..|:....|:..:|.
Mouse     3 FQDLIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAIP-SHRCWVPILDNDTASDNGSRI 66

  Fly    74 IPKKQDGSFENCFMYNVPYDSNATND--------------ANQTRSPI------PCNNGWIYDRK 118
            :      |.::....::|.|||...|              .|.|...:      ||.:||:||:.
Mouse    67 L------SQDDLLRISIPLDSNLRPDKCRRYIQPQWHLLHLNGTFPTVTEPDTEPCVDGWVYDQS 125

  Fly   119 EVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCV 183
            .. ..:..|:::.||..:...:.:..:|..|..:|.:..|.::|..||.    |..:||::...:
Mouse   126 TF-LSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGYIMGGHLSDKFGRK----LIFTCSLLKMAI 185

  Fly   184 SVVCKDF-PCF---AASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFT-LGACLL 243
            :..|..| |.|   .:.||::|:..:.......:|.||....|::.||  :||.|..: :|..||
Mouse   186 TETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSALLILEWTSPKFQALV--MALIFIASGVGQTLL 248

  Fly   244 PWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAA-----KANGK 303
            ..||:...||.|..:.:::|:..:::.:....||..||:...|..:.::.:|:||     |.:|.
Mouse   249 GGLAFAFRNWHHLQLALSVPMFLLLIPTRWLSESARWLIMANKPQKSLKELKKAACVNRIKNSGD 313

  Fly   304 IIS-EEVWSEMRECYELKFANEQLGKQYTSLDLFKTFPRL--VVLTILIVTWMTVALAYDAHVRV 365
            .:: |.|.:.|:|  ||:.|.    .:.:.||||:| |.|  .:..:..|.:::|.......:.
Mouse   314 ALTLEVVKTIMKE--ELEAAQ----TKPSPLDLFRT-PNLRKRICLLSFVRFVSVMSLLGLLIN- 370

  Fly   366 VEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSL-------------- 416
            ::.|..::|:...|..:|.|||.::....::.:||:......|.:...|.|
Mouse   371 IQYLSNNVFLLQCLYGVVCIPANVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQILRV 435

  Fly   417 FVGILKGHWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLS 481
            |:..|.|      |..:|...:|:.:      |:|::||::|...|.::.|.|..|..||||::.
Mouse   436 FLSTLGG------AISSASITSTLVH------ANELVPTIIRATALGVVGIAGSAGGALSPLLMI 488

  Fly   482 THRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKR 526
            ...|...||..|..::..:|.|:.|.|||||...:|.::.:.|.:
Mouse   489 LTTYSASLPWIIYGILPFLGGLVALLLPETKNQPLPDSIQDIENK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	136/548 (25%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	99/394 (25%)
Slc22a19	NP_659034.1	Sugar_tr	11..525	CDD:331684	135/547 (25%)
Slc22a19	NP_659034.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..551		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940