DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_033229.3	Gene:	Slc22a12 / 20521	MGIID:	1195269	Length:	553	Species:	Mus musculus

Alignment Length:	577	Identity:	140/577 - (24%)
Similarity:	240/577 - (41%)	Gaps:	98/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKRLLF----------WMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQK 70
            :|..|.||   ||          |:.....|       :.|...:| :|.|.|..|:. ..|:..
Mouse    10 VGGLGRFQ---LFQTVALVTPILWVTTQNML-------ENFSAAVP-HHRCWVPLLDN-STSQAS 62

  Fly    71 NRG-----------IPKKQDGSFENCFMYNVPY----DSNATNDANQTRSPIPCNNGWIYDRKEV 120
            ..|           ||...|.....|..:..|.    :||||.......:..||.:||:||....
Mouse    63 IPGDLGPDVLLAVSIPPGPDQQPHQCLRFRQPQWQLTESNATATNWSDAATEPCEDGWVYDHSTF 127

  Fly   121 PYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSV 185
             ..:|.|.::.||:.:.....:..::..|.:||....|..:|..||...|..:.....:.|..:.
Mouse   128 -RSTIVTTWDLVCNSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTAAA 191

  Fly   186 VCKDFPCFAASRF-----VAGLSMNYCFV----------PIYILTLENVGIKYRTLVGNLALTFF 235
            ....||.:...||     |||:.||...:          |: ::||..:|
Mouse   192 FMPTFPLYCLFRFLLASAVAGVMMNTASLLMEWTSAQGSPL-VMTLNALG--------------- 240

  Fly   236 FTLGACLLPWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAA-- 298
            |:.|..|...:||.:.:||...:.|:.|.....:.|...|||..||::|||:|:.::.::..|
Mouse   241 FSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYSWWLPESARWLITVGKLDQGLQELQRVAAV 305

  Fly   299 ---KANGKIISEEVWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLTIL-IVTWMTVALAY 359
               ||.|..::.||   :|...|.:.:.::.|   .||......|.|...||: ::.|......:
Mouse   306 NRRKAEGDTLTMEV---LRSAMEEEPSRDKAG---ASLGTLLHTPGLRHRTIISMLCWFAFGFTF 364

  Fly   360 DAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVML---LCAASSLFV--- 418
            ......::.|.::||:..:|..:|:.|.....:||:.|:||:....:.::   ||..|::.|
Mouse   365 YGLALDLQALGSNIFLLQALIGIVDFPVKTGSLLLISRLGRRLCQVSFLVLPGLCILSNILVPHG 429

  Fly   419 -GILKGHWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLST 482
             |:|:     |..|:........|:.....::||:.|||:|...:.:..:..:.||:|.|||...
Mouse   430 MGVLR-----SALAVLGLGCLGGAFTCITIFSSELFPTVIRMTAVGLCQVAARGGAMLGPLVRLL 489

  Fly   483 HRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWTLRCRDRKINED 539
            ..|...:|:.:..:|.|:..|..|.|||||...:|.|:.:.:|:..     :|:..|
Mouse   490 GVYGSWMPLLVYGVVPVLSGLAALLLPETKNLPLPDTIQDIQKQSV-----KKVTHD 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	136/554 (25%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	95/395 (24%)
Slc22a12	NP_033229.3	2A0119	11..526	CDD:273328	136/554 (25%)
Slc22a12	NP_033229.3	MFS	147..516	CDD:119392	95/395 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950