DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	547	Identity:	151/547 - (27%)
Similarity:	267/547 - (48%)	Gaps:	51/547 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGL-------PE 66
            ::..|...|:||.||:|:...:......|||.:.|.:|:...|..:|||......|       ||
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    67 SE----QKNRGIPKKQDGSFENCFMYNVPYDSNATNDA------------NQTRSPIPCNNGWIY 115
            .|    .....:|.::.|. .:|..|.:    .|||.:            |::...:.|:..|.|
Mouse    69 EEWNLTTPELHVPAERRGQ-GHCHRYLL----EATNTSSELSCDPLTAFPNRSAPLVSCSGDWRY 128

  Fly   116 DRKEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIG 180
            ..   .:.:|.::::.||........:..:..:|.:.|....|:..|..||| .::|. ||..:|
Mouse   129 VE---THSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRL-IIYLI-SCFGVG 188

  Fly   181 --GCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLL 243
              |.|.....:|..|...||:.|:.....::..:::..|.||.|.|.:|| :.:..|||||..:|
Mouse   189 ITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVG-IVIQMFFTLGIIIL 252

  Fly   244 PWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEE 308
            |.:||...:|:...:.::||....:|...:.||||.||::..:.::.:::::..||.|||.:|..
Mouse   253 PGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSN 317

  Fly   309 VWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTD 372
            .       .|:...:|::... :.|||.:| |::...| ||:..|.|.|:.|...|..:.::..:
Mouse   318 Y-------SEITVTDEEVSNP-SCLDLVRT-PQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGN 373

  Fly   373 IFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL-KG-HWNASTAAIAAR 435
            ::|.|.:|.|||:|..::.:|.::|:||:...:|..::...|.|....| :| .|..:|.|...|
Mouse   374 LYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGR 438

  Fly   436 FFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFII-TLVS 498
            ...|||:.:.....||:.||.||..|:::.:.:...|.:::| |:......:..||:.|. .|.|
Mouse   439 LGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILAS 503

  Fly   499 VIGALIILFLPETKGATMPQTLDEAEK 525
            |.|.|::| ||||||..:|:|:::.||
Mouse   504 VCGGLVML-LPETKGIALPETVEDVEK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	147/531 (28%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	107/374 (29%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	147/531 (28%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	107/380 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844080
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850