Protein Alignment CG5592 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 560
• Identity: 163/560 - (29%)
• Similarity: 268/560 - (47%)
• Gaps: 52/560 - (9%)

  Fly    10 ENFLLFIGDFGPFQKR--LLFWMMPAAFLFAFTYFGQIFMILLPKNHWCR---VRELE---GLPE 66
            ::.|..:|:||.|||:  ||..::.|:  .|..|.|.:|:...|.:| ||   |.||.   |...
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISAS--LAPIYVGIVFLGFTPDHH-CRSPGVAELSQRCGWSP 66

  Fly    67 SEQKNRGIP---KKQDGSF-ENCFMYNVPYDSNATN--------DANQTRSPI-PCNNGWIYDRK 118
            :|:.|..:|   ...:.|| ..|..|.|.::.:..:        .||::..|: ||.:||:||
Mouse    67 AEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYD-- 129

  Fly   119 EVPYESIATEYNWVCDKRDFGTYSVVVYFVGCI-----VGCLCFGFITDHSGRLPALFLANSCSM 178
             .|..||.||:|.||     |....|..|..|:     :|.|..|:|.|..||...|.:....:.
Mouse   130 -TPGSSIVTEFNLVC-----GDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTS 188

  Fly   179 IGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLL 243
            :.|.::.|..|:......|.:.|:.....:|..|.|..|.||..||.... :.....||:|...|
Mouse   189 LSGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTA-ILYQVAFTVGLVGL 252

  Fly   244 PWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEE 308
            ..:||.|.:||...:.|:||....:|.....||||.||:|..:..:.:.:|::.|:.|.|:...:
Mouse   253 AGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPAD 317

  Fly   309 VWSEMRECYELKFANEQLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTD 372
            :   ...|.| :.|:|:....:.  |||:| |.|...| ||:..|.:.|:.|...:..|.....:
Mouse   318 L---KMMCLE-EDASERRSPSFA--DLFRT-PSLRKHTLILMYLWFSCAVLYQGLIMHVGATGAN 375

  Fly   373 IFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL--KGHWNASTAAIAAR 435
            :::.|..|||||.||..:.::.:|||||...::|..|:..|:.|.:..:  :.||...|.|...|
Mouse   376 LYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGR 440

  Fly   436 FFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFIITLVSV 499
            ..||:...:.....:|:.||.:|..|:.:.:.:..:|.:.:| :|......::.||:.:..::.:
Mouse   441 MGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGL 505

  Fly   500 IGALIILFLPETKGATMPQTLDEAEKRWTLRCRDRKINED 539
            ....:.|.||||||..:|:|::|||   .|..|..|..|:
Mouse   506 SAGAVTLLLPETKGVALPETIEEAE---NLGRRKSKAKEN 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	112/404 (28%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	154/531 (29%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)