DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	524	Identity:	143/524 - (27%)
Similarity:	251/524 - (47%)	Gaps:	16/524 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73
            :.:.|..:|..|.||...:..::....|.|.....|.|...:|.:| ||......|.:.......
Mouse     3 FNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHH-CRPPANANLSKDGGLEAW 66

  Fly    74 IPKKQDGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCDKRDF 138
            :|..:.|..|:|..:  |:..|.| :||.|....||.:||:||....| .:|.||:|.||..|.|
Mouse    67 LPLDKQGRPESCLRF--PFPHNGT-EANGTGVTEPCLDGWVYDNSTFP-STIVTEWNLVCSHRAF 127

  Fly   139 GTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLS 203
            ...:..::.||.::|.:.||::.|..||...|.|....:.:.|..:....::..:...|.::|:|
Mouse   128 RQLAQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMS 192

  Fly   204 MNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMI 268
            :....:....|.:|.:.|..|..||.| :.:.::||..||..:||.:.:|||..:.|::|.....
Mouse   193 LASIAINCMTLNMEWMPIHTRAYVGTL-IGYVYSLGQFLLAGIAYAVPHWRHLQLAVSVPFFVAF 256

  Fly   269 LTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANE-QLGK-QYT 331
            :.|....||..|..|.|::|..:..::..|:.|||  .||......|..:.....| .|.| |.:
Mouse   257 IYSWFFIESARWYSSSGRLDLTLRALQRVARINGK--QEEGAKLSIEVLQTSLQKELTLNKGQAS 319

  Fly   332 SLDLFK--TFPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPMLL 394
            :::|.:  |..||.:  .|.:.|...:.||...|..::.....:::...:...|::||..|..|:
Mouse   320 AMELLRCPTLRRLFL--CLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLV 382

  Fly   395 LDRIGRKPMMSAVMLLCAASSLFVGIL-KGHWNASTA-AIAARFFATMAYNVGQQWASEILPTVL 457
            ::.:||:|...|.:||.....|..||: :||....|: |:..:.....::|....:..|:.||::
Mouse   383 INSMGRRPAQLASLLLAGICILVNGIIPRGHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTMI 447

  Fly   458 RGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDE 522
            |..||.:.:.|.::|:::|||:..|..:|..:|:||...|.|..:.:...||||.|..:|.|:.:
Mouse   448 RQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQPLPDTVQD 512

  Fly   523 AEKR 526
            .:.|
Mouse   513 LKSR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	140/507 (28%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	96/373 (26%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	140/507 (28%)
		MFS	129..499	CDD:119392	96/374 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844054
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950