DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and Slc22a27

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	591	Identity:	143/591 - (24%)
Similarity:	253/591 - (42%)	Gaps:	110/591 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQ-KRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNR 72
            ::..|..:|..|.|| .:::|.::..|.:...... :.|...:| ||.|.|..|:....|:..:|
Mouse    28 FQELLNQVGSLGRFQILQIVFLLLLNAIVVPHIAM-ENFTAAIP-NHRCWVPILDNDTASDNGSR 90

  Fly    73 GIPKKQDGSFENCFMYNVPYDSNATND--------------ANQTRSPI------PCNNGWIYDR 117
            .:      |.::....::|.|||...:              .|.|.|.:      ||.:||:|||
Mouse    91 IL------SQDDLLRISIPLDSNLRPEKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDR 149

  Fly   118 KEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGC 182
            ... ..:|.||::.||:.:...:.:...:.:|..:|.:..|.::|..||...|    :|:::...
Mouse   150 SNF-LSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFIL----TCALLQFA 209

  Fly   183 VSVVCKDF-PCF---AASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLL 243
            ::..|..| |.|   .:.||:||||:....|..::|.||....|:.|::..| |:....:|..:.
Mouse   210 ITETCVAFAPSFFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKFLTMMAAL-LSCAPNIGYMIS 273

  Fly   244 PWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAA-----KANGK 303
            ..||::...|.|..:.:::||.|.::.:....||..||:...|..:.::.:::.|     |.:|.
Mouse   274 AGLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKELRKVAHMNGMKNSGD 338

  Fly   304 IISEEVWSEMRECYELKFANEQLGKQYTSL-DLFKTF---PRLVVLTILIVTWMTVALAYDAHVR 364
            :..|.|.:.|:       |..:..|...|| |||.|.   .|:.||:.:.: :.||:: :...|.
Mouse   339 LTMEIVRTSMK-------AELEAAKTKPSLRDLFHTSILRKRICVLSFMRL-FFTVSI-FGLAVH 394

  Fly   365 VVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRK----PMMS--AVMLLCAA---------- 413
            :..:....|.:.|.:|:|. |...::...:|:.|||:    .:||  .:.:|.|.
Mouse   395 LQHLSSNIILLQFLISALA-ILVSVIGPFVLNHIGRRITYLVLMSLRGIFILIAVFVPQEMQTLR 458

  Fly   414 ----------SSLFVGILKGHWNASTAAIAARFFATMAYNVGQQWASEILPTVLRGQGLAIINIM 468
                      |||.||:.:.|.|                        |:|||.||...:.:|...
Mouse   459 IIMATLAEGISSLCVGVSRLHTN------------------------ELLPTTLRATAVGVIGFF 499

  Fly   469 GQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWTLRCRD 533
            |..|:.||||.:....||..:|.......|:..|..:..|||||...:|.:..:....|....:.
Mouse   500 GNSGSFLSPLFMLLATYYANMPWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHDVGNDWKESRKG 564

  Fly   534 RKINED 539
            :|  ||
Mouse   565 KK--ED 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	138/561 (25%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	97/406 (24%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	109/445 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940