Protein Alignment CG5592 and SLC22A7

DIOPT Version :10

• Sequence 1: NP_647996.1
• Gene: CG5592 / 38662
• FlyBaseID: FBgn0035645
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 149/599 - (24%)
• Similarity: 263/599 - (43%)
• Gaps: 90/599 - (15%)

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPE--SEQK- 70
            :|..|..:|.|||||.|.:..:.....|....:...||:..:|. |.|   .|.|.|.  |.|.
Human     3 FEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPA-HRC---ALPGAPANFSHQDV 63

  Fly    71 --NRGIPKKQDGSFENC--FMYNVPYDSNATNDANQTR-------SPIPCNNGWIYDRKE----- 119
              ...:|::.||:..:|  |.|.....:....:..|:|       :.:||:.||.||..|
Human    64 WLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTI 128

  Fly   120 ------------------------------VPYESI-------------------------ATEY 129
                                          :|:|..                         ..|:
Human   129 ATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSWRESLGGLLSGMEW 193

  Fly   130 NWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFA 194
            :.||:::.....:...:|.|.:||.:.||:::|..||...|.:|...:::.|..|.....:..||
Human   194 DLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFA 258

  Fly   195 ASRFVAGLSM---NYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHY 256
            .:|.:.|.::   ....:|:....||.:.:::||:.|.|:.| |:|.|..||..:.|:|.:||..
Human   259 ITRTLTGSALAGFTIIVMPLGEAELEWLDVEHRTVAGVLSST-FWTGGVMLLALVGYLIRDWRWL 322

  Fly   257 AMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKF 321
            .:.|.||....||:....|||..||::.|.|......:...|:.||:.:.|:.:|:  |......
Human   323 LLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQ--EAVSKVA 385

  Fly   322 ANEQLGKQYTSLDLFKTFPRLVVLTI-LIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEI 385
            |.|::.::.:.||||:| |||..::: .:|.|..|..:|......|..|..:::.|..|...||:
Human   386 AGERVVRRPSYLDLFRT-PRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVEL 449

  Fly   386 PAGIVPMLLLDRIGRKPMMSAVML---LCAASSLFVGILKGHWNASTAAIAARFFATMAYNVGQQ 447
            |:.::..|.:...||:...:..:|   |...:.|.|......| ::..|:..:.|:..|:.....
Human   450 PSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSW-STVLAVMGKAFSEAAFTTAYL 513

  Fly   448 WASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETK 512
            :.||:.|||||..|:.:..::|::|..|:||.......:..||......::::.|...|.||||:
Human   514 FTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETR 578

  Fly   513 GATMPQTLDEAEKR 526
            .|.:|:|:.:.|::
Human   579 QAQLPETIQDVERK 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	MFS_SLC22	113..509	CDD:340875	110/462 (24%)
SLC22A7	XP_011512558.1	MFS	106..563	CDD:475125	111/461 (24%)