DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5592 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_598741.2	Gene:	Slc22a13 / 102570	MGIID:	2143107	Length:	551	Species:	Mus musculus

Alignment Length:	529	Identity:	158/529 - (29%)
Similarity:	264/529 - (49%)	Gaps:	42/529 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELE----GLPESEQKNRGIPK 76
            :||||.||.||...|....||.||..|||:||: |.:.|.|.|..::    .|..:||....||.
Mouse    11 VGDFGRFQVRLTILMGIPNFLAAFFIFGQVFMV-LDEAHHCSVSWVKNHTFNLSAAEQLAISIPN 74

  Fly    77 KQDGSFENCFMYNVPYDSNATNDA-----NQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCDKR 136
            ...|..|:|.|:..|.||.:..|.     |:|::   |::||.|.....  :|:..|::.|||::
Mouse    75 DTAGRPESCLMFRPPPDSASLEDILSHRFNETQA---CDSGWDYPENRP--QSLKKEFDLVCDRK 134

  Fly   137 DFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFV-- 199
            :....|..|:..|.:||.|.||.:.|..||.|:|.:....|.|....:.....|..:.|.|||
Mouse   135 NLKKTSQSVFMAGLLVGALVFGPVCDWIGRRPSLLMQVLLSGITSMATAFVSSFELYLALRFVLA 199

  Fly   200 ---AG--LSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMV 259
               ||  ||.|       :|..|.||..:||....||.: ...||..:|..|||.:.|||...:.
Mouse   200 TANAGFLLSTN-------VLISEWVGPSWRTQAVVLAQS-NVALGQMVLAGLAYGVRNWRLLQIT 256

  Fly   260 VALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELKFANE 324
            ...|::.:.....:.||||.||:|.|:.:...:::::||..||:.:|.|:.:::        ..|
Mouse   257 GTAPVLLLFFYFWVLPESPRWLLSQGRTEEAKQLVQKAALVNGRPLSPELLNQL--------VPE 313

  Fly   325 QLGKQYTSLDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAG 388
            :.|....:||||: .|.|..:| |||..|...:|.|.:....|.....||::|..:...||:|..
Mouse   314 KTGPSGNALDLFR-HPHLRKVTLILIAVWFVDSLVYYSLSFQVGDFGLDIYVTQLIFGAVEMPGR 377

  Fly   389 IVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWN--ASTAAIAARFFATMAYNVGQQWASE 451
            .:.:|:::::|||......:.|.....:.:..:.|...  .:..|:..:|.:..|:.:...:.:|
Mouse   378 FLSVLMMEKLGRKWSQLCTLTLAGIMYIIIIFIPGDLPTVVTVLAVVGKFASAAAFTISYVYTAE 442

  Fly   452 ILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIILFLPETKGATM 516
            :.||::|..|:.:::|..::|.:::|||:...:|::.:||.|...:.:...|:...||||:|.|:
Mouse   443 LFPTIIRQTGMGLVSIFSRVGGIITPLVMLLEQYHQAIPMVIFGSLPIGAGLLCALLPETRGQTL 507

  Fly   517 PQTLDEAEK 525
            ..||.:.|:
Mouse   508 KDTLQDLEQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	155/520 (30%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	103/377 (27%)
Slc22a13	NP_598741.2	2A0119	12..510	CDD:273328	155/520 (30%)
Slc22a13	NP_598741.2	MFS	139..500	CDD:119392	103/377 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843781
Domainoid	1	1.000	69	1.000	Domainoid score	I9569
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850