DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a8

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	539	Identity:	139/539 - (25%)
Similarity:	236/539 - (43%)	Gaps:	53/539 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVREL----EGLPESEQKNRGIPKK 77
            |..|.||...:..:.....|.|.....|.|...:| :|.|:..:.    ....|:..:....|..
Frog    11 GGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIP-DHKCKANDTGYQSNSTDETGYERLSAPLD 74

  Fly    78 QDGSFENCFMY-NVPY---DSNATNDANQTRSPIPCNNGWIYDRKEVPYESIATEYNWVCDKRDF 138
            .:|..:.|..| .:.:   .||:|.:.:...:..||..||.|.:.|.. .:|.||::.||.::..
Frog    75 ANGQPDRCLEYVEIQWRMVGSNSTWNNSSELATRPCTIGWEYSKDEFS-STIITEWDLVCGRKTR 138

  Fly   139 GTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPCFAASRFVAGLS 203
            ...:..:|..|.:||.:..|.::|..||...|..:.....:.|..:....::..:...||:.|::
Frog   139 RQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQLAVSGVCAAFSPNYLSYCIFRFLTGMA 203

  Fly   204 MNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYAMVVALPIVFMI 268
            ::...:....|.:|.|..:.||:.|.|| .|.:|.|..||..|||.:.:||...:.|:||.....
Frog   204 LSGIGLNTTALIVEWVPTRVRTVTGTLA-GFSYTAGQLLLAGLAYGMRDWRWLQLCVSLPFFIYF 267

  Fly   269 LTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANG------KIISEEVWSEMRECYELKFANEQLG 327
            |.:...|||..||:..||.::.::.:::.|..||      ||..|.:.|||.:  ||..|.
Frog   268 LYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKKEEGEKITLESLKSEMIK--ELASAK---- 326

  Fly   328 KQYTSLDLFKTFPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIFITFSLSSLVEIPAGIVPM 392
            ..|:.:||.:|.....:...|.:.|.:.:.||......::..:..|::...:...|:.||.:|..
Frog   327 SSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVSIYLIQVIFGAVDFPAKLVSA 391

  Fly   393 LLLDRIGRK--PMMSAVM--------------LLCAASSLFVGILKGHWNASTAAIAARFFATMA 441
            ..:..:|||  ..||.::              |....:||.| ..||       .:||.|.....
Frog   392 TAMIYVGRKFTQFMSLILGGIAIIANIFVPNELQTVRTSLAV-FGKG-------CLAASFSCIFL 448

  Fly   442 YNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGALIIL 506
            |      .:|:.|||:|..||.:.:.|.::|.:::|||......|..:|:.|.....:|..|.:.
Frog   449 Y------TTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPIISGLCVF 507

  Fly   507 FLPETKGATMPQTLDEAEK 525
            |||||....:|.|::|.||
Frog   508 FLPETVNKPLPDTIEEVEK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	135/531 (25%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	100/389 (26%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	111/426 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100