DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a16

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_002936981.2	Gene:	slc22a16 / 100488673	XenbaseID:	XB-GENE-961385	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	140/564 - (24%)
Similarity:	251/564 - (44%)	Gaps:	74/564 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRE-------------- 60
            |....::|.||.||..:.|.....|......|...:|:.:.|| ..||..|
Frog     2 ERLFDYVGHFGRFQALIYFSSAFQAISCGIHYLASVFIAITPK-FICRAPENISSVLLPNASTLR 65

  Fly    61 LEGLPES-EQKNRGIPKKQDGSF-----------ENCFMYNVPYDSNATNDANQTRSPIPCNNGW 113
            ||.:.|. ..|:..:.|:::|..           ||.......||.|.|        ...|:||:
Frog    66 LEDVWELWTPKDYLVVKQENGDIWELNQCSRFKRENTSYLTYSYDGNKT--------LFSCSNGY 122

  Fly   114 IYDRKEVPYESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSM 178
            .||...:. .||.|:::.||::..........:..|.::|.:.||.|.|..||...|:|.::...
Frog   123 YYDNTNLE-SSIVTDWHLVCEREWLAKLIQPTFMFGVLIGAVIFGDIADRVGRRLILWLTSTGQF 186

  Fly   179 IGGCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLL 243
            :.|.......|:..|...||:..:..:..:|.:::...|.||||.|:. .::.:..||.:|..::
Frog   187 LFGIAVAFTFDYYSFVIVRFLLAMVSSGYYVVVFVYVTEYVGIKARSW-ASMHVHAFFAVGVMIV 250

  Fly   244 PWLAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEE 308
            ..:.:::..|..|.::::|..:..:|...:.||:|.||.|.||       .||..|..|.|   |
Frog   251 SLVGFLVRTWWMYQIILSLTTLPFVLCCWMLPETPFWLYSQGK-------HKEVEKLIGTI---E 305

  Fly   309 VW---------SEMRECYELKFANEQLGKQYTSLDLFK--TFPRLVVLTILIVTWMTVALAYDAH 362
            .|         ||:....|.:.......|:::.||||.  :|.|..|...||  |.|.:|.|...
Frog   306 KWNKISTPCKLSELCSVQETQKTEMDTLKKHSVLDLFYNWSFARRTVTVWLI--WFTGSLGYYVF 368

  Fly   363 VRVVEILDTDIFITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL----KG 423
            ......|..:.::...|:|.||||:.||....:|:|||:..::..::|   |::..||:    :.
Frog   369 ALNSVNLGGNEYLNLFLTSAVEIPSYIVACFGMDKIGRRNTLAPFLIL---SAVICGIIMLIPQD 430

  Fly   424 HWNASTAAIA----ARFFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHR 484
            |   ||..||    .:|...:|:.:...:.:|:.||::|...:...::|.::|::::|..:....
Frog   431 H---STVTIAMSMGGKFSIAVAFGLIYLYTAELYPTIVRSLAVGSGSMMCRIGSVVAPFCVYLTD 492

  Fly   485 YYRPLPMFIITLVSVIGALIILFLPETKGATMPQTLDEAEKRWT 528
            .:..:|..::.:::.:..::.|.||||.|..:..|::||.:..|
Frog   493 VWIFMPQMLVGIMAFLTGVLTLKLPETLGVPLTSTIEEAAEMGT 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	135/546 (25%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	94/386 (24%)
slc22a16	XP_002936981.2	MFS_SLC22A16_CT2	111..517	CDD:340933	106/433 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000