DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a2

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	158/545 - (28%)
Similarity:	269/545 - (49%)	Gaps:	56/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQK--- 70
            ::..|..||:|..|||::...:...:.:|:..|.|.:|:..:| ::.|   ...|:||...:
Frog     4 FDELLEHIGEFDAFQKQIFILLCFISVVFSPIYVGIVFLGFVP-DYRC---VSAGIPEPSNECEW 64

  Fly    71 --NRGIPKKQDGS--FENCFMYNVPYDS---NATNDANQTRSPIP---CNNGWIYDRKEVPYESI 125
              |...|.....|  ...|:.|:|.::|   |.||.:....|.:|   |.:||.|:   ....|:
Frog    65 TLNYTGPNGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITNCKDGWDYN---TTGSSL 126

  Fly   126 ATEYNWVCD---KRDFGTYSVVVYFVGCI-----VGCLCFGFITDHSGRLPALFLANSCSMIG-- 180
            .||:|.||.   |.||        |..|:     :|.|..|:|.|..||.|  ||.:|..:.|
Frog   127 VTEFNLVCGDSWKLDF--------FQSCVNIGFFIGGLISGYIADRFGRKP--FLISSILITGIF 181

  Fly   181 GCVSVVCKDFPCFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPW 245
            |.:.....::|.....||:.|.....|::..|||..|.||:::|..|| :.....||:|..||..
Frog   182 GILMAFAPNYPLVVTFRFIQGFVSKGCWLSGYILVAEFVGLEHRRTVG-IVYQAAFTVGLLLLSG 245

  Fly   246 LAYVISNWRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVW 310
            :|||:.:||...|.|.:|..|.:......||||.||:|..:......::...||.|||::.:.:
Frog   246 VAYVLPHWRWLQMTVTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVPDFL- 309

  Fly   311 SEMRECYELKFANEQLG-KQYTS-LDLFKTFPRLVVLT-ILIVTWMTVALAYDAHVRVVEILDTD 372
                   |...|:|:.| ||..| |||.:| |::...| ||:..|.|.|:.|...:..:.....:
Frog   310 -------ESLTADEEAGEKQVPSFLDLVRT-PQIRKHTLILMYIWFTCAVVYQGSIMHMGSTAEN 366

  Fly   373 IFITFSLSSLVEIPAGIVPMLLLDRIGRK-PMMSAVMLLCAASSLFVGILKGH-WNASTAAIAAR 435
            |:..|.:|:|||.|:.|:.::.:||:||: |.:...::......:...|..|: |...|.:..:|
Frog   367 IYFDFFISALVEFPSAILIIVTVDRVGRRYPWLVCCIITGITCLITAFIPHGYSWLIITLSCVSR 431

  Fly   436 FFATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSP-LVLSTHRYYRPLPMFIITLVSV 499
            ...|::|.:.....:|:.||.:|..|:.:.:.|..:|.:::| :|......::.||:.:..:::.
Frog   432 MGITVSYEMVCLVNAELYPTFIRNLGIMVCSSMCDLGGVITPFIVYRLAAIWQELPLIVFAVLAT 496

  Fly   500 IGALIILFLPETKGATMPQTLDEAE 524
            :..:::.|||||||..:|:|::|||
Frog   497 VSGILVYFLPETKGRALPETIEEAE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	152/530 (29%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	106/380 (28%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	152/530 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000