DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a6

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_002937540.1	Gene:	slc22a6 / 100487511	XenbaseID:	XB-GENE-5842250	Length:	552	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	141/543 - (25%)
Similarity:	249/543 - (45%)	Gaps:	49/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKN-- 71
            ::..|..||..|.:|...:..:....|:.|.....|.|...:|: |.|::.     ...|:.|
Frog     3 FQEILESIGGMGRYQVIHVVLLSLPVFMLASHNLMQNFTAAIPR-HRCQIN-----GSFEETNFT 61

  Fly    72 ----RG-IPKKQDGSFENCFMYNVP-YD---SNATNDANQTRSPIPCNNGWIYDRKEVPYESIAT 127
                |. :|.|..|.|..|..|..| |.   .|.|.:.::..:. .|.:||:||..|.. .:|.|
Frog    62 GPWLRALVPMKPTGEFSKCLRYTTPQYHLLMDNFTQNVDELETE-TCVDGWVYDHSEFA-STIIT 124

  Fly   128 EYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPC 192
            :::.||:.|.....:..:|..|.:||.:.||.::|..||.|....:|....:.|..:....::..
Frog   125 QWDLVCNHRRMRQVAQSIYMAGVLVGSVVFGGLSDKFGRRPLNIWSNLQMSVTGICAAFSPNYIW 189

  Fly   193 FAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALT-----FFFTLGACLLPWLAYVISN 252
            :...||:.|.:::...:..|.|.:|.:.      .||.|.|     :.:|:|..:|..||::|.:
Frog   190 YCIFRFLTGTALSGIVLNSYSLIVEWIP------TGNRAFTSTATGYCYTMGQLVLVGLAFMIRD 248

  Fly   253 WRHYAMVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANG------KIISEEVWS 311
            |....:..:||..|..|.|...|||..||:..||.:...:.:|:.||.||      |:..|.:.|
Frog   249 WHWLQLAASLPFFFYFLYSWWIPESGRWLVLSGKPEVACKALKKVAKINGKKEAGEKLTVEVLKS 313

  Fly   312 EM-RECYELKFANEQLGKQYTSLDLFKTFPRLVVLTILI-VTWMTVALAYDAHVRVVEILDTDIF 374
            .| ||....|.:.      |:.|||.:| |.:..::..| .||.:.:.||......::.....|:
Frog   314 SMQREISASKHST------YSVLDLVRT-PVVRRISFCISCTWFSTSFAYYGLALDLQSFGVSIY 371

  Fly   375 ITFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGIL--KGHWNASTA-AIAARF 436
            |...:...|:|||......::..|||: ::.|:.|:.|..::.|.|.  :.:....|: |:..:.
Frog   372 IIQIIFGTVDIPAKFFSYFVMTYIGRR-VLQALTLILAGIAILVNICVPQDYQTVRTSMAVFGKG 435

  Fly   437 FATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIG 501
            ....::|....:..|:.|||:|..|:.:..:|.::|.:::||...|...|..||:.|...:.::.
Frog   436 CLAASFNCLFLYTGELYPTVIRQSGMGLGTMMARLGGIIAPLAQMTGDIYHSLPLIIFGCLPILS 500

  Fly   502 ALIILFLPETKGATMPQTLDEAE 524
            .:...|||||.|..:|:|:::.|
Frog   501 GIAGCFLPETLGVPLPETIEDVE 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	137/528 (26%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	97/383 (25%)
slc22a6	XP_002937540.1	MFS_SLC22A6_OAT1_like	102..508	CDD:341004	108/421 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100