DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5592 and slc22a5

DIOPT Version :9

Sequence 1:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	556	Identity:	146/556 - (26%)
Similarity:	261/556 - (46%)	Gaps:	47/556 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRE------LEGLPES 67
            |:....|:|..|||..| ||.::...::....:...|..:.....|.|||..      ||....:
Zfish     4 YDEDTAFLGQTGPFFIR-LFCLLNLIYISTGLHGLYIVFVAASPAHRCRVDVNLTEDWLEASAPT 67

  Fly    68 EQKNRGIPKKQDGSFENCFMYNVPYDSNATNDANQTRSP-------IP---CNNGWIYDRKEVPY 122
            |..:.|     |.....|:.|::   ...||.:.|..||       ||   |.:||:|. .:|.:
Zfish    68 ETLSNG-----DLQVSQCWRYSL---QTLTNLSGQGYSPGQINITDIPRERCEDGWVYS-ADVYH 123

  Fly   123 ESIATEYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVC 187
            .:|.:|::.|||.......:....::|.::|.:..|.::|..||...||    .|:....:.:..
Zfish   124 STIVSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLF----GSLAAEALLMFA 184

  Fly   188 KDFP----CFAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAY 248
            :.|.    .|....|..|......::..::|..|.:....|.|...|.....:.:|..||||:|:
Zfish   185 QSFSPSWLIFCVLYFFIGAFQISLYITAFVLGNEVLSGSLRVLFTTLGAFLHYCVGYMLLPWVAF 249

  Fly   249 VISNWRHYAMVVA-LPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSE 312
            .|.:||....|:: |.:|::.|..|: ||||.||:|.|.|.....::::||:.| ::.:.||..:
Zfish   250 AIRHWRTLLRVLSGLTVVYIPLWWLI-PESPRWLLSQGHVQESEAILRDAARKN-RVPAPEVIFK 312

  Fly   313 MRECYELKFANEQLGKQYTSLDLFKT--FPRLVVLTILIVTWMTVALAYDAHVRVVEILDTDIFI 375
            ..:..|..|..    .:|::||:.:|  ..|...:.:|:  ||.:.:.|.........|..|.|:
Zfish   313 QSQIKEAAFQK----SKYSALDVLRTSNIRRTTFMCLLL--WMAINIGYFGLSLNTTNLSGDPFL 371

  Fly   376 TFSLSSLVEIPAGIVPMLLLDRIGRKPMMSAVMLLCAASSLFVGILKGHWNASTAAI--AARFFA 438
            ...||::.|:||.||...||....|:|::||.:::.....|.|.::.........|:  |.:|..
Zfish   372 NCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLVIGGGFLLLVQLIPDRLQTLALALEMAGKFGF 436

  Fly   439 TMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGAL 503
            ||::.|...:.:|:.|||||..|:.:.:...::|::.:|.::....:.|.||..::..:::..:|
Zfish   437 TMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYIIFLGTFNRHLPYVLMGSLTITASL 501

  Fly   504 IILFLPETKGATMPQTLDEAEKRWTLRCRDRKINED 539
            ..||||||.|..:|:.|::.:|..:...||::..||
Zfish   502 ANLFLPETFGKVLPENLEQMQKSRSFPGRDKQSVED 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	138/526 (26%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	96/376 (26%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	137/525 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950