DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf133 and HRD1

DIOPT Version :9

Sequence 1:	NP_937894.1	Gene:	Rnf133 / 386611	MGIID:	2677436	Length:	339	Species:	Mus musculus
Sequence 2:	NP_014630.1	Gene:	HRD1 / 854149	SGDID:	S000005373	Length:	551	Species:	Saccharomyces cerevisiae

Alignment Length:	169	Identity:	39/169 - (23%)
Similarity:	65/169 - (38%)	Gaps:	23/169 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse   180 WK--RLTRELKKAFGQLQVRVLKEGDEEVNPNADSCVICFE--AYKPNEIV--------RILTCK 232
            ||  |..::|......:.|..|:....:.|    .|:||.:  .:.||:..        :.|.|.
Yeast   318 WKIWRNNKQLDDTLVTVTVEQLQNSANDDN----ICIICMDELIHSPNQQTWKNKNKKPKRLPCG 378

Mouse   233 HFFHKNCIDPWILAHGTCPMCKCDILKALG--IQMDIEDGTDSLQVLMSNELPGTLSPVEEETN- 294
            |..|.:|:..|:....|||:|:..:....|  :|......:|........:..|..:..:...|
Yeast   379 HILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANE 443

Mouse   295 YELPPARTSSKVTHVQEHPTSSANAGSQPPEAEETSHPS 333
            .:|.|.||:|  ..::..||.  |..:.......||.||
Yeast   444 VDLLPTRTTS--PDIRIVPTQ--NIDTLAMRTRSTSTPS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf133	NP_937894.1	PA_GRAIL_like	43..159	CDD:239037
Rnf133	NP_937894.1	zf-RING_2	211..254	CDD:290367	14/52 (27%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	39/169 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910