DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-epsilon58 and DPB2

DIOPT Version :9

Sequence 1:	NP_647995.1	Gene:	DNApol-epsilon58 / 38661	FlyBaseID:	FBgn0035644	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_680197.2	Gene:	DPB2 / 832272	AraportID:	AT5G22110	Length:	526	Species:	Arabidopsis thaliana

Alignment Length:	545	Identity:	172/545 - (31%)
Similarity:	267/545 - (48%)	Gaps:	59/545 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RKRITNTFKLCGFLIRSENSSYL---AEQLLPFDAAERDKWLTVITENLQ-SQKLLTPHVERAAL 69
            ||:|...||..|:.::.:....:   |:|....|..|.   :.::.:||| :.|..|  |:..::
plant     8 RKKIQKKFKNRGYNLKFDALDEILVFADQFPDDDDGEA---IDLLLDNLQETHKSST--VDAESV 67

  Fly    70 EKAINELNRVGL----DEGET---VFALIDAFTVPRFRYNQRIKKFELDTQPRQLLTAPRMKSDY 127
            ...||.|  :|.    :|..|   ..|:||||.||:|.|:...|||...|....:......|:..
plant    68 RGLINRL--LGAHNAPEEPTTSASSLAIIDAFLVPKFGYDSVKKKFNEHTSSLPIHGEASAKTAL 130

  Fly   128 MQQRYAMLLQKTLRHDLFA-PAVIQDGVGAEAQAKKF---KLQFAENLLATSAMKEAVVLGLLTQ 188
            .::|:.:|.|:..|.:.|: ||.       :|:..:|   ::...::|::....|  .|:|:::|
plant   131 YRERFMLLSQRVSRAEHFSRPAF-------DAEMSQFENNEISSIQSLISQRGRK--WVMGVISQ 186

  Fly   189 LKEGKFYVEDPTGCVQLDLTGARFHAGFFCEGCFVLAEGNYN-NGVLKVDGLGFPPAE------P 246
            |::|.||:||.:..|::||:.|:...|||.|...:||||... ||:.:|...||||.|      .
plant   187 LEDGHFYLEDLSASVEIDLSKAKITTGFFTENTIILAEGEMQVNGIFQVITCGFPPLEDRDKTLK 251

  Fly   247 ANSSRAFFGTANTWGGESAK--LLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVG 309
            |:|...|||     ||...|  ::|    |.:|||.....|.|.|||:.||...||.||..:..|
plant   252 AHSEYDFFG-----GGTLTKEEMIK----LADLERQAVNDTFVILSDIWLDDEEVMRKLETVLDG 307

  Fly   310 YDSCP--PQAIVLMG-----PFTASTRNHHELRHHLDALGGLAAGCEQLKKQTDLILVPSSEDPT 367
            ::|..  |...|.||     |...|..::..||.....||.:.....:||:.:..:.:|..||..
plant   308 FESVETVPSLFVFMGNFCSRPCNLSFGSYSSLREQFGKLGRMIGNHPRLKENSRFLFIPGPEDAG 372

  Fly   368 APNILPRAPIPECLAAGLLKAWPRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFP--EDT 430
            ...:|||..:|:.|...|....|....::||||:::..|:||..|.||:.:..|:.|..|  |:|
plant   373 PSTVLPRCALPKYLTEELRNIIPNAIFSSNPCRVKFYNQEIVFFRQDLLYRMRRSCLVTPSSEET 437

  Fly   431 SQIEQHFARTIVCQGHLVPIHPIAMPVHWDYDPALWLYPLPDLIVMGDSCQSFSSSQHGCTVLNT 495
            :...:|...||..|.||.|:..:..|:.|:||.||.|||.|..||:||..:.......|.|..|.
plant   438 NDPFKHLVYTITHQSHLCPLPLMVQPIIWNYDHALRLYPTPHTIVLGDKSEQEVCKFGGTTCFNP 502

  Fly   496 GSFVKSKFAFKVYIPATRTIEDSEI 520
            ||| .:...|..|.|:|:.:|.|.:
plant   503 GSF-STDSTFVAYRPSTQEVELSAL 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon58	NP_647995.1	Dpoe2NT	7..76	CDD:371965	18/70 (26%)
DNApol-epsilon58	NP_647995.1	DNA_pol_E_B	287..484	CDD:367778	70/205 (34%)
DPB2	NP_680197.2	DNA_pol_E_B	285..489	CDD:281968	70/203 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	116	1.000	Domainoid score	I1979
eggNOG	1	0.900	-	-		E1_KOG3818
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2015
Inparanoid	1	1.050	214	1.000	Inparanoid score	I1236
OMA	1	1.010	-	-		QHG54736
OrthoDB	1	1.010	-	-		D375960at2759
OrthoFinder	1	1.000	-	-		FOG0004867
OrthoInspector	1	1.000	-	-		oto4031
orthoMCL	1	0.900	-	-		OOG6_102104
Panther	1	1.100	-	-	LDO	PTHR12708
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4545
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840