DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-epsilon58 and pole2

DIOPT Version :9

Sequence 1:	NP_647995.1	Gene:	DNApol-epsilon58 / 38661	FlyBaseID:	FBgn0035644	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001025641.1	Gene:	pole2 / 595029	XenbaseID:	XB-GENE-973812	Length:	527	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	214/521 - (41%)
Similarity:	317/521 - (60%)	Gaps:	10/521 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LRKRITNTFKLCGFLIRSENSSYLAEQLLPFDAAERDKWLTVITENLQSQKLLTPHVERAALEKA 72
            |:.::|:.||:.|.|:|:|.|.||:|.|...:..|.:..:..|.:.::.|.|.:..:|::.:|.|
Frog     6 LKSKVTSAFKMHGLLLRAEASKYLSEVLSSVNEVELEDVIDSIIDAVEKQPLSSNMIEKSTVETA 70

  Fly    73 INELNRVGLDEGETVFALIDAFTVPRFRYNQRIKKF---ELDTQPR-QLLTAPRMKSDYMQQRYA 133
            :.|.:|...:..|.:|.:|.||.:||:.||...|||   ::.|.|. .|..:.|.|::..::||.
Frog    71 VQECSRSCDETIEHIFNIIGAFDIPRYVYNSERKKFLPLKMTTLPSPNLFGSARDKAELFRERYT 135

  Fly   134 MLLQKTLRHDLFAPAVIQDGVGAEAQAKKFKLQFAENLLA-TSAMKEAVVLGLLTQLKEGKFYVE 197
            :|.|:|.||:||.|.||  |...:....||:|:..|.||. |:.:.|.:|||::|||||||.::|
Frog   136 ILQQRTHRHELFTPPVI--GAHPDESRSKFQLKTVETLLGNTAKVGEVIVLGMITQLKEGKIFLE 198

  Fly   198 DPTGCVQLDLTGARFHAGFFCEGCFVLAEGNYNNGVLKVDGLGFPPAEPANSSRAFFGTANTWGG 262
            ||||.||||||.|:||:|.:.|.|||||||.|.:.:..::..||||.||::::||::|..|.:||
Frog   199 DPTGAVQLDLTNAQFHSGLYTESCFVLAEGWYEDKIFHINAFGFPPTEPSSTTRAYYGNMNFFGG 263

  Fly   263 ESAKLLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVGYDSCPPQAIVLMGPFTAS 327
            .|:..:|.|..|::||..|.:...|||||:.||...|.|||..:|.||.:.||...:..|.|:::
Frog   264 PSSTSVKTSVKLRQLEEENEDAMFVFLSDLWLDQVEVTEKLHTMFSGYSTAPPTCFIFCGNFSSA 328

  Fly   328 T--RNH-HELRHHLDALGGLAAGCEQLKKQTDLILVPSSEDPTAPNILPRAPIPECLAAGLLKAW 389
            .  :|| ..|:.....|..:......:.|.:..:.||..|||....||||.||.:.:.....:..
Frog   329 PYGKNHIRSLKDSFKILADIICEYPHIHKSSRFVFVPGPEDPGPGFILPRPPIADHITEEFRQRV 393

  Fly   390 PRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFPEDTSQIEQHFARTIVCQGHLVPIHPIA 454
            |.:...|||||:|||||:|||.|.||:.|.|||.:.||.:|..|..||.:||:.||.|.|:.|..
Frog   394 PFSIFTTNPCRIQYCTQEIVVFREDLVNKMCRNCVRFPNNTLDIPNHFVKTILSQGLLTPLPPFV 458

  Fly   455 MPVHWDYDPALWLYPLPDLIVMGDSCQSFSSSQHGCTVLNTGSFVKSKFAFKVYIPATRTIEDSE 519
            .||:|.||.||.|||||||:|:.|....|:.:...|..:|.|||.:|.|:||||.|:::|.|||:
Frog   459 SPVYWAYDYALRLYPLPDLVVIADKYDPFTITNTECLTINPGSFPRSGFSFKVYYPSSKTAEDSK 523

  Fly   520 I 520
            :
Frog   524 L 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon58	NP_647995.1	Dpoe2NT	7..76	CDD:371965	20/67 (30%)
DNApol-epsilon58	NP_647995.1	DNA_pol_E_B	287..484	CDD:367778	84/199 (42%)
pole2	NP_001025641.1	Dpoe2NT	4..73	CDD:314989	20/66 (30%)
		HYS2	12..>205	CDD:333347	73/194 (38%)
		DNA_pol_E_B	288..488	CDD:309247	84/199 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3579
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2015
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1851
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249486at33208
OrthoFinder	1	1.000	-	-		FOG0004867
OrthoInspector	1	1.000	-	-		oto103208
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4545
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060