Protein Alignment PolE2 and Pole2

DIOPT Version :10

• Sequence 1: NP_647995.1
• Gene: PolE2 / 38661
• FlyBaseID: FBgn0035644
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001162579.1
• Gene: Pole2 / 299112
• RGDID: 1311962
• Length: 527
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 214/526 - (40%)
• Similarity: 318/526 - (60%)
• Gaps: 20/526 - (3%)

  Fly     8 LRKRITNTFKLCGFLIRSENSSYLAEQLLPFDAAERDKWLTVITENLQSQKLLTPHVERAALEKA 72
            ||.|..:.|||.|.|:|||.:.||.|.|......|.::.|..|.:.::.|.|.:..:||:.:|.|
  Rat     6 LRSRTVSAFKLRGLLLRSEATKYLTEALQSVTELELEENLEKIIDAVEKQPLSSNMIERSVVEAA 70

  Fly    73 INELNRVGLDEG-ETVFALIDAFTVPRFRYNQRIKKFELDTQPRQLL--TAP------RMKSDYM 128
            :.|.:: .:||. |.:|.:|.||.:|.|.||...|||    .|..:.  .||      |.|::..
  Rat    71 VQECSQ-SVDETIEHIFNIIGAFDIPHFIYNSERKKF----LPLSMTNHAAPTIFGTARDKAELY 130

  Fly   129 QQRYAMLLQKTLRHDLFAPAVIQDGVGAEAQAKKFKLQFAENLL-ATSAMKEAVVLGLLTQLKEG 192
            ::||.:|.|:|.||:||.|.||  |...:....||:|:..|.|| :||.:.:.:|||::||||||
  Rat   131 RERYTILHQRTHRHELFTPPVI--GSHPDESGSKFQLKTIETLLGSTSKVGDVIVLGMITQLKEG 193

  Fly   193 KFYVEDPTGCVQLDLTGARFHAGFFCEGCFVLAEGNYNNGVLKVDGLGFPPAEPANSSRAFFGTA 257
            ||::|||||.|||||:.|:||:|.:.|.|||||||.:.:.|...:..||||.||::::||::|..
  Rat   194 KFFLEDPTGTVQLDLSKAQFHSGLYTEACFVLAEGCFEDQVFHANAFGFPPTEPSSTTRAYYGNI 258

  Fly   258 NTWGGESAKLLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVGYDSCPPQAIVLMG 322
            |.:||.|...:|.||.|::||..|.:...|.:|||.||...|:|||..:|.||...||...:|.|
  Rat   259 NFFGGPSNASVKASAKLRQLEEENKDAMFVIVSDVWLDQVQVLEKLHVMFSGYSPAPPTCFILCG 323

  Fly   323 PFTASTRNHHELRHHLDALGGLA-AGCE--QLKKQTDLILVPSSEDPTAPNILPRAPIPECLAAG 384
            .|:::....::::...|:|..|| ..||  .:.:.:..:.||..|||...:||||.|:.|.:...
  Rat   324 NFSSAPYGKNQVQALKDSLKSLADIICEYPSIHQSSRFVFVPGPEDPGFGSILPRPPLAESITQE 388

  Fly   385 LLKAWPRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHFPEDTSQIEQHFARTIVCQGHLVP 449
            ..:..|.:...|||||:|||||:|::.|.||:.|.|||.:.||..:..|..||.:|::.||||.|
  Rat   389 FRQRVPFSVFTTNPCRIQYCTQEIIIFREDLVNKMCRNCVRFPSSSLDIPTHFVKTVLSQGHLAP 453

  Fly   450 IHPIAMPVHWDYDPALWLYPLPDLIVMGDSCQSFSSSQHGCTVLNTGSFVKSKFAFKVYIPATRT 514
            :.....||:|.||..|.:||:|||:|:.|....|:.:...|..:|.|||.:|.|||||:.|:::|
  Rat   454 LPLYVSPVYWAYDYTLRVYPVPDLLVIADKYDPFTVTNTECLCINPGSFPRSGFAFKVFYPSSKT 518

  Fly   515 IEDSEI 520
            :|||::
  Rat   519 VEDSKL 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolE2	NP_647995.1	Dpoe2NT	7..76	CDD:463494	24/67 (36%)
		DNA_pol_E_B	286..483	CDD:461142	78/199 (39%)
Pole2	NP_001162579.1	Dpoe2NT	2..74	CDD:463494	24/67 (36%)
		DNA_pol_E_B	287..489	CDD:461142	79/201 (39%)