DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-epsilon58 and dpb2

DIOPT Version :9

Sequence 1:	NP_647995.1	Gene:	DNApol-epsilon58 / 38661	FlyBaseID:	FBgn0035644	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_596521.1	Gene:	dpb2 / 2541347	PomBaseID:	SPBP8B7.14c	Length:	594	Species:	Schizosaccharomyces pombe

Alignment Length:	531	Identity:	152/531 - (28%)
Similarity:	240/531 - (45%)	Gaps:	63/531 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KLCGFLIRSENSSYLAEQLLPFDAAERDKWLTV-ITENLQSQKLL--------TPHVERAA---- 68
            |.||...||:     .|.||...|   ..|..| .|:.:.::.||        .||..|.:
pombe    55 KKCGSQWRSQ-----CEPLLDEIA---KTWKRVHETQPIVTRPLLIPVLANLNVPHEVRVSSLAR 111

  Fly    69 ---LEKAINELNRVGLDEGETV-----FALIDAFTVPRFRYNQRIKKFELDTQPRQLLTAPRMKS 125
               ||...:.||....:..||:     |.::|||.:|:|:|:...|.|.|..|...|:.:....:
pombe   112 VQTLETTGSFLNSSNSEIRETIKNEKYFRVLDAFKMPKFKYDSSRKVFVLSKQSPTLMASASACT 176

  Fly   126 DYMQQRYAMLLQKTLRHDLFAPAVIQDGVGAEAQAKKFKLQFAENLLATSAMKEAVVLGLLTQLK 190
            |.:.:|:.::..:.||::.|......   |:.:|...::|....|||. .|....::.||||...
pombe   177 DMLNRRFNVVYSRILRNESFQTPSFS---GSFSQTGTYQLTPIRNLLG-RAGNTFLLFGLLTIAP 237

  Fly   191 EGKFYVEDPTGCVQLDLTGARFHAGFFCEGCFVLAEGNY-NNGVLKVDGLGFPPAEPANSSRAFF 254
            :|..::||....||||::.|....|.||.||.||..|.: ::|:..|..||.||.|..::|....
pombe   238 DGTLWLEDLDSQVQLDVSQAEQGFGLFCPGCLVLVNGQFLSSGLFLVFELGHPPIERRDASLKAL 302

  Fly   255 GTANTWG-GESAKLLKYSAGLQELERTNTETTIVFLSDVRLDLPVVMEKLRQLFVGYDS--CPPQ 316
            ...:..| ...||.|   |.|:..|:.......|.:|:|.||.......|.::|..|:|  ..|.
pombe   303 NNLDILGLNMDAKQL---ALLRHAEQAYQSQAFVCISEVHLDNHQTFYALEKIFQKYESSEAVPF 364

  Fly   317 AIVLMGPFTAST-RNHHELRHHLDALGGLAAGCEQLKK---QTDLILVPSSEDPTAPN---ILPR 374
            .|:|.|.|.:|. .|......:.:....|||..|:..|   :|..|.||...||...|   ::|:
pombe   365 CIILCGSFMSSAFHNSGSSIQYKEGFNKLAASLEKFPKICEKTKFIFVPGPNDPWTTNGISLMPK 429

  Fly   375 APIPECLAAGLLKAWPRTQLATNPCRLQYCTQQIVVCRLDLMAKFCRNTLHF---PEDTSQI--- 433
            ..||......:.:....|..|:||||:.:.:|::::.|.|:..:|.||:|.|   |:.||.|
pombe   430 HSIPLHFVNRIQRVCKHTIFASNPCRIIFFSQEVLIYRDDISGRFQRNSLKFGKTPQGTSNINSI 494

  Fly   434 ---------EQHFARTIVCQGHLVPIHPIAMPVHWDYDPALWLYPLPDLIVMGDS-CQSFSSSQH 488
                     ::...:|::.|.||.|......|:.||:|.||.::|||..:.:.|| ..:|.....
pombe   495 PLAEQQVHQQRKLVKTVLDQSHLSPFPSRTRPILWDFDYALSVFPLPSCMGLIDSESSAFDVHYG 559

  Fly   489 GCTVLNTGSFV 499
            ||...|.|:.:
pombe   560 GCPTFNPGALL 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-epsilon58	NP_647995.1	Dpoe2NT	7..76	CDD:371965	19/74 (26%)
DNApol-epsilon58	NP_647995.1	DNA_pol_E_B	287..484	CDD:367778	65/221 (29%)
dpb2	NP_596521.1	DNA_pol_E_B	333..556	CDD:281968	66/222 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	92	1.000	Domainoid score	I2010
eggNOG	1	0.900	-	-		E1_KOG3818
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I1183
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004867
OrthoInspector	1	1.000	-	-		oto100954
orthoMCL	1	0.900	-	-		OOG6_102104
Panther	1	1.100	-	-	LDO	PTHR12708
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R333
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850