DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13287 and prdm8b

DIOPT Version :9

Sequence 1:	NP_001261454.1	Gene:	CG13287 / 38660	FlyBaseID:	FBgn0035643	Length:	470	Species:	Drosophila melanogaster
Sequence 2:	NP_001098575.1	Gene:	prdm8b / 557162	ZFINID:	ZDB-GENE-060526-174	Length:	570	Species:	Danio rerio

Alignment Length:	459	Identity:	131/459 - (28%)
Similarity:	176/459 - (38%)	Gaps:	153/459 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PPQHAELRISTSPQ-QSPQQNQ--TTNHN-----NNNETPTSPPGGK-------TTLKRAFDVAF 70
            ||..:..::..|.. .:||..:  |..||     .||.  ||||..|       ::.||.|.
Zfish   205 PPARSSPKLGRSDGFSNPQDGKPSTDFHNLARDLENNR--TSPPSDKEAEILSESSGKRKFS--- 264

  Fly    71 LMMPDER---IKQKQAEKQARLQEALHHHHHQQQQQQMSHYPTDLSPRGTSSQPPSPAALEYISL 132
             .|.|.|   :.|....|:.....|         ||....|..|.|.|..|
Zfish   265 -DMEDSRNSGLSQPTKSKEELANSA---------QQYRGVYGLDESRRAFS-------------- 305

  Fly   133 LEARQRYPQISIRSPRVYDDPSVVIPLVDSPEAPSTSSPPPPMRSAFTKVASSSLSTSSSSPSTT 197
                                             ||.|......|||||:|..||.....|..:::
Zfish   306 ---------------------------------PSVSETTETKRSAFTEVKKSSQGLKHSGKNSS 337

  Fly   198 SRLESPVDAGAPPLSPDQ--LSCHSI----SPP-----------LVTPPPRTNSGGQNPNPLPAN 245
            ...|:. :||.|..:|.:  |:...:    .||           ..|..|:.:.||.......:.
Zfish   338 FNSENK-EAGRPNSNPAEKHLNIRQVLSETQPPQSRMETSSIGSAFTSVPQHSGGGSERKSAFSQ 401

  Fly   246 PIVYHNFRPEYQFNGAFQAVNPMQALQAQQRLKQQLLYTRPPGPGNPNGG--------------- 295
            |            :..|..::|:.       :..:||   |....:|..|
Zfish   402 P------------SRTFSQLSPLV-------MAPKLL---PAVDCHPTVGDTVSSSRLYQADHLA 444

  Fly   296 ----GPTMQANSPP----GPPSEFLHAYPGFAPPPHPFAVSQPLQNPAAAAILSTLIPPTLASTF 352
                |..:.:|.|.    ...|.||:. ..|.|     ..|.|:|....:|:  ||:||:..| .
Zfish   445 AKLQGSELGSNCPVPSGIAKQSPFLYT-TAFWP-----KTSGPIQLQMPSAL--TLLPPSFTS-L 500

  Fly   353 TLTAQNVCAKCNISFRMTSDLVYHMRSHHKSEVACDP-NRRKREEKLRCPVCQETFRERHHLTRH 416
            .|.|||.|||||.|||||||||||||||||.|.|.:| .:|:|||||:||:|.|:|||||||:||
Zfish   501 CLPAQNWCAKCNASFRMTSDLVYHMRSHHKKEFAMEPLVKRRREEKLKCPICNESFRERHHLSRH 565

  Fly   417 MTAH 420
            ||:|
Zfish   566 MTSH 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13287	NP_001261454.1	C2H2 Zn finger	360..380	CDD:275368	18/19 (95%)
		zf-C2H2_2	363..>418	CDD:289522	41/55 (75%)
		C2H2 Zn finger	400..420	CDD:275368	15/19 (79%)
prdm8b	NP_001098575.1	SET	32..134	CDD:279228
		C2H2 Zn finger	508..528	CDD:275368	18/19 (95%)
		zf-C2H2	548..569	CDD:278523	15/20 (75%)
		C2H2 Zn finger	549..569	CDD:275368	15/19 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595504
Domainoid	1	1.000	47	1.000	Domainoid score	I12076
eggNOG	1	0.900	-	-		E33208_3BI9J
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25623
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16516
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6448
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.920