DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13287 and ZNF488

DIOPT Version :9

Sequence 1:NP_001261454.1 Gene:CG13287 / 38660 FlyBaseID:FBgn0035643 Length:470 Species:Drosophila melanogaster
Sequence 2:NP_001333861.1 Gene:ZNF488 / 118738 HGNCID:23535 Length:340 Species:Homo sapiens


Alignment Length:351 Identity:113/351 - (32%)
Similarity:151/351 - (43%) Gaps:79/351 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 LSP----RGTSSQPPSPAALEYISLLEARQRYPQISI-RSPRVYDDPSVVIPLVDSPEAPSTSSP 171
            |||    |...|:|......:.:.|.:..:..|:.:: |:.|  |..|..:.|:.:|..|....|
Human    26 LSPSAENRWRLSEPELGRGCKPVLLEKTNRLGPEAAVGRAGR--DVGSAELALLVAPGKPRPGKP 88

  Fly   172 PPP------MRSAFTKVASSSLSTSSSSPSTTSRLESPVDAGAPPLSPDQLSCHSISPPLVTPPP 230
            .||      .:||||::           |....|   .|||.|.....|..:....:|.|....|
Human    89 LPPKTRGEQRQSAFTEL-----------PRMKDR---QVDAQAQEREHDDPTGQPGAPQLTQNIP 139

  Fly   231 RTNSGGQ------------------NPNPLPANPIVYHNFRPEYQFNGAFQAVNPMQALQAQQRL 277
            |..:|.:                  .|...||.       |||  ....|.|.....||.....|
Human   140 RGPAGSKVFSVWPSGARSEQRSAFSKPTKRPAE-------RPE--LTSVFPAGESADALGELSGL 195

  Fly   278 ---KQQLLYTRPPGPGNPNGGGPTMQA---NSP-----PGPPSEFLHAYPGFAPPPHPFAVSQPL 331
               .....:.|...|....|....:||   |:|     .|.|:.:|.......|||         
Human   196 LNTTDLACWGRLSTPKLLVGDLWNLQALPQNAPLCSTFLGAPTLWLEHTQAQVPPP--------- 251

  Fly   332 QNPAAAAILSTLIPPTLASTFTLTAQNVCAKCNISFRMTSDLVYHMRSHHKSEVA-CDP-NRRKR 394
              .:::.....|:||||.| ..|:.||.|||||:|||:|||||:|||||||.|.| .|| ::::|
Human   252 --SSSSTTSWALLPPTLTS-LGLSTQNWCAKCNLSFRLTSDLVFHMRSHHKKEHAGPDPHSQKRR 313

  Fly   395 EEKLRCPVCQETFRERHHLTRHMTAH 420
            ||.|.||||||.|||||||:||||:|
Human   314 EEALACPVCQEHFRERHHLSRHMTSH 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13287NP_001261454.1 C2H2 Zn finger 360..380 CDD:275368 16/19 (84%)
zf-C2H2_2 363..>418 CDD:289522 40/56 (71%)
C2H2 Zn finger 400..420 CDD:275368 17/19 (89%)
ZNF488NP_001333861.1 Important for transcriptional repression activity. /evidence=ECO:0000250|UniProtKB:Q5HZG9 72..187 30/137 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..180 27/125 (22%)
C2H2 Zn finger 277..297 CDD:275368 16/19 (84%)
Nuclear localization signal. /evidence=ECO:0000255|PROSITE-ProRule:PRU00768 298..305 4/6 (67%)
C2H2 Zn finger 319..339 CDD:275368 17/19 (89%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159354
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7944
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006844
OrthoInspector 1 1.000 - - otm41240
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR16516
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6448
SonicParanoid 1 1.000 - - X7618
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
77.010

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