DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18586 and 4CL1

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_175579.1	Gene:	4CL1 / 841593	AraportID:	AT1G51680	Length:	561	Species:	Arabidopsis thaliana

Alignment Length:	543	Identity:	136/543 - (25%)
Similarity:	250/543 - (46%)	Gaps:	56/543 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MEVKQKLLNAMCTYDDKLKIWSGREAPSLFSPN-LSIGEIIFGD---------MVNNPKLIAQIS 58
            ||.:....|:...:..||        |.::.|| ||:.:.||.:         ::|.|
plant    12 MEKQSNNNNSDVIFRSKL--------PDIYIPNHLSLHDYIFQNISEFATKPCLINGP------- 61

  Fly    59 ITEDIVLTREDLHMNAMRVASYMRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAY 123
              ...|.|..|:|:.:.::|:....:|:.|.|:|.::..:.........|..|.|....|.:..:
plant    62 --TGHVYTYSDVHVISRQIAANFHKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAANPFF 124

  Fly   124 EEACIAKLFGITKPRLIFCDGDEYEKVKSATKDLQVTIVTMRNH-----PRGSVRIQDVL--TTP 181
            ..|.|||....:..:||..:....:|:|....|..|.||.:.::     |.|.:|..::.  ||.
plant   125 TPAEIAKQAKASNTKLIITEARYVDKIKPLQNDDGVVIVCIDDNESVPIPEGCLRFTELTQSTTE 189

  Fly   182 VMQNFQPLRLKDGIDHTLAILSSSGTSGFPKAVTISNSHKIIVDYMAI----NNSNIQYTSSTLD 242
            ..:....:.:..  |..:|:..||||:|.||.|.:  :||.:|..:|.    .|.|:.:.|..:.
plant   190 ASEVIDSVEISP--DDVVALPYSSGTTGLPKGVML--THKGLVTSVAQQVDGENPNLYFHSDDVI 250

  Fly   243 WC-------SGLSMAITSGVFSTTSIIADCDFDPGLFCRAIGKYRISMVLLSSSYLAIFANCPEF 300
            .|       ..|:..:..|:....:|:....|:..|....|.:.::::..:....:...|...|.
plant   251 LCVLPMFHIYALNSIMLCGLRVGAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSSET 315

  Fly   301 ESADLSSLNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCYGLTELNSAGSVNLNFDEKP-----NS 360
            |..||||:..|..|.:....|::..|.::..:..|...||:||.....:::|.|.::|     .:
plant   316 EKYDLSSIRVVKSGAAPLGKELEDAVNAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGA 380

  Fly   361 VGRAIRGIKIKVID-EQGEAQEPNVVGEICFHNSQKWAGYYKNPDETRQIQDSENWIHTGDLGYV 424
            .|..:|..::|::| :.|::...|..||||....|...||..||..|.:..|.:.|:||||:|.:
plant   381 CGTVVRNAEMKIVDPDTGDSLSRNQPGEICIRGHQIMKGYLNNPAATAETIDKDGWLHTGDIGLI 445

  Fly   425 DKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKPGT 489
            |.|..||::||||:::||:.....|:|:|.::...|::.:..|..:.:...|:...|.:||...:
plant   446 DDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEAAGEVPVAFVVKSKDS 510

  Fly   490 QLEAQDVVEYVRKRITAKFKQLN 512
            :|...||.::|.|::.. :|::|
plant   511 ELSEDDVKQFVSKQVVF-YKRIN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	130/512 (25%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	122/482 (25%)
4CL1	NP_175579.1	PLN02246	16..560	CDD:215137	134/539 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920