DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18586 and 4CL2

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_188761.1	Gene:	4CL2 / 821678	AraportID:	AT3G21240	Length:	556	Species:	Arabidopsis thaliana

Alignment Length:	544	Identity:	128/544 - (23%)
Similarity:	252/544 - (46%)	Gaps:	44/544 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PSLFSPN-LSIGEIIFGD---------MVNNPKLIAQISITEDIVLTREDLHMNAMRVASYMRNM 84
            |.::.|| |.:.:.||.:         ::|.|        |.: |.|..|:|:.:.::|:.:.|:
plant    28 PDIYIPNHLPLHDYIFENISEFAAKPCLINGP--------TGE-VYTYADVHVTSRKLAAGLHNL 83

  Fly    85 GLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDGDEYEK 149
            |:.|.|:|.::..::........|..|.|....:.:..:..|.|:|....:..:||.......:|
plant    84 GVKQHDVVMILLPNSPEVVLTFLAASFIGAITTSANPFFTPAEISKQAKASAAKLIVTQSRYVDK 148

  Fly   150 VKSATKDLQVTIVTMRNH--PRGSVRIQDVLTTPVMQNFQPLRLKDGIDHTLAILSSSGTSGFPK 212
            :|:...| .|.|||..:.  |...:|..: ||.........:..|...:..:|:..||||:|.||
plant   149 IKNLQND-GVLIVTTDSDAIPENCLRFSE-LTQSEEPRVDSIPEKISPEDVVALPFSSGTTGLPK 211

  Fly   213 AVTISNSHKIIVDYMAI----NNSNIQYTSSTLDWC-------SGLSMAITSGVFSTTSIIADCD 266
            .|.:  :||.:|..:|.    .|.|:.:....:..|       ..|:..:...:....:|:....
plant   212 GVML--THKGLVTSVAQQVDGENPNLYFNRDDVILCVLPMFHIYALNSIMLCSLRVGATILIMPK 274

  Fly   267 FDPGLFCRAIGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRSRLS 331
            |:..|....|.:.::::.::....:...|..||.|..||||:..|..|.:....|::..:.::..
plant   275 FEITLLLEQIQRCKVTVAMVVPPIVLAIAKSPETEKYDLSSVRMVKSGAAPLGKELEDAISAKFP 339

  Fly   332 HDCLNFCYGLTELNSAGSVNLNFDEKP-----NSVGRAIRGIKIKVID-EQGEAQEPNVVGEICF 390
            :..|...||:||.....:::|.|.::|     .:.|..:|..::|::| :.|::...|..||||.
plant   340 NAKLGQGYGMTEAGPVLAMSLGFAKEPFPVKSGACGTVVRNAEMKILDPDTGDSLPRNKPGEICI 404

  Fly   391 HNSQKWAGYYKNPDETRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENV 455
            ..:|...||..:|..|....|.:.|:||||:|::|.|..||::||||:::||:.....|:|:|::
plant   405 RGNQIMKGYLNDPLATASTIDKDGWLHTGDVGFIDDDDELFIVDRLKELIKYKGFQVAPAELESL 469

  Fly   456 IAEMPNVLEACVFGIWDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQ 520
            :...|.:.:..|..:.:...|:...|.:|:...:.:...::.::|.|::.. :|::| .....|.
plant   470 LIGHPEINDVAVVAMKEEDAGEVPVAFVVRSKDSNISEDEIKQFVSKQVVF-YKRIN-KVFFTDS 532

  Fly   521 IVRSGNRKTNRSAVKEHFLKNYNN 544
            |.::.:.|..|..::........|
plant   533 IPKAPSGKILRKDLRARLANGLMN 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	126/534 (24%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	118/493 (24%)
4CL2	NP_188761.1	PLN02246	14..553	CDD:215137	127/539 (24%)
4CL2	NP_188761.1	4CL	32..546	CDD:213272	126/528 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920