DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and Acsf2

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	124/516 - (24%)
Similarity:	227/516 - (43%)	Gaps:	54/516 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NLSIGEIIFGDMVNNPKLIAQISITEDIVLTREDLHMNAMRVASYMRNMGLGQTDIVGVMGRHTT 100
            |.::||.:.......|...|.:.|.|:|.|....|.....|.||.:.::||.:.|.:|:.|.::.
  Rat    71 NKTVGECLDATAQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSY 135

  Fly   101 HQSAVAYACFFNGTPLHALHNAYE----EACIAKL--FGITKPRLIFCDGDEYEKVKSATKDLQ- 158
            ....:..|....|..|.:::.||:    |..:.|:  .||..|:. |.....|..:|....:|:
  Rat   136 AWVLIQLATAQAGIILVSVNPAYQASELEYVLRKVGCKGIVFPKQ-FKTQQYYNILKQVCPELEK 199

  Fly   159 --------------VTIVTMRNHPRGSVRIQDVLTT-PVMQNFQPLRLKDGI---DHTLAILSSS 205
                          .|::::.....|::.:.:|:.. ...||...||...|.   ...:.|..:|
  Rat   200 AQPGALKSERLPDLTTVISVDAPLPGTLLLDEVVAAGGKEQNLAQLRYHQGFLSCYDPINIQFTS 264

  Fly   206 GTSGFPKAVTISNSHKIIVDYMAINNSN-----IQYTSST-----------LDWCSG-LSMAITS 253
            ||:|.||..|:|: |.|      :||||     ::..:.|           |..|.| :...:.|
  Rat   265 GTTGNPKGATLSH-HNI------VNNSNLIGQRLKMPAKTAEELRMVLPCPLYHCLGSVGGTMVS 322

  Fly   254 GVFSTTSIIADCDFDPGLFCRAIGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSC 318
            .|...|.:::...|:......||.:.:.:::..:.:......|.|:|.|.|.:::...:..||..
  Rat   323 VVHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTTIRGGVIAGSLA 387

  Fly   319 SLEVQRKVRSRLSHDCLNFCYGLTELNSAGSVNL---NFDEKPNSVGRAIRGIKIKVID-EQGEA 379
            ..|:.|.:.|:::...|...||.||.:....:|.   ..::|..||||.:...:.:::: |.||.
  Rat   388 PPELIRAIISKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNMETGEL 452

  Fly   380 QEPNVVGEICFHNSQKWAGYYKNPDETRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQN 444
            .:.|:.||:|........||:..|.:|.:....:.|..|||:..:|:.|:..::.|.|||:....
  Rat   453 TKLNMPGELCIRGYCVMQGYWGEPQKTFETVGQDRWYRTGDIASMDEQGFCRIVGRSKDMIIRGG 517

  Fly   445 IMYYPSEIENVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRIT 505
            ...||:|:|:...:.|.|.||.|.|:.|...|:|..|.:..|.|.....:::..:.:.:|:
  Rat   518 ENIYPAELEDFFHKHPQVQEAQVVGVKDDRMGEEICACIRLKSGETTTEEEIKAFCKGKIS 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	124/516 (24%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	120/497 (24%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	124/516 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810