DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18586 and DIP2B

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	637	Identity:	131/637 - (20%)
Similarity:	229/637 - (35%)	Gaps:	185/637 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IGEIIFGDMVNNPKLIAQI-----SITEDIVL--------------TREDLHMNAMRVASYMRNM 84
            :|:|...|:|...:.:|:|     ..|.|.||              :...||..|.|:||.:.:.
Human   976 LGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDK 1040

  Fly    85 G-LGQTDIVGVMGRHTTHQSAVAYACFFNG------TPLHA------------LHNAYEEACIAK 130
            | |...|.|.::........|..|.|.:.|      .|.||            :.:..:.|||
Human  1041 GHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACI-- 1103

  Fly   131 LFGITKPRLIFCDGDEYEKVKSATKDLQV--TIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLKD 193
            |...|..||:      ..:..:|..|::.  ||:...:.||..:               |...|.
Human  1104 LTSQTLMRLL------RSREAAAAVDVKTWPTIIDTDDLPRKRL---------------PQLYKP 1147

  Fly   194 GIDHTLAILS-SSGTSGFPKAVTISNSHKIIVDYMAIN----NSNIQ---YTSSTLDWC----SG 246
            .....||.|. |..|:|....|.:|:|        |:|    ...:|   |:|..:..|    .|
Human  1148 PTPEMLAYLDFSVSTTGMLTGVKMSHS--------AVNALCRAIKLQCELYSSRQIAICLDPYCG 1204

  Fly   247 LSMAI--TSGVFS--TTSIIADCDFDPGLF--CRAIGKYRISMVLLSSSYLAI----FANCPEFE 301
            |..|:  ...|:|  .:.:|...:.:..||  ...:.:|:|.....|.|.:.:    ..|..|..
Human  1205 LGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVL 1269

  Fly   302 SADLSSLNYVIFGGSSCSLEVQRKVR-------SRLSHD--------------------CLNFCY 339
            .....:|:.|    .:|.:..:.:.|       |:|..|                    ||....
Human  1270 KTRGINLSCV----RTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRVNVAICLQGTS 1330

  Fly   340 G------LTELNSAGSVNLNFDEK--PNSV-----GRAIRGIKIKVIDEQGEAQEP---NVVGEI 388
            |      ..:|.|.....:...|:  |.|:     |:.:.|:|:.:::.  |.:.|   :.:|||
Human  1331 GPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVNP--ETKGPVGDSHLGEI 1393

  Fly   389 CFHNSQKWAGYYKNPDETRQIQDSEN-------------------WIHTGDLGYV---------- 424
            ..::....:|||       .|.|||.                   |..||.||:|
Human  1394 WVNSPHTASGYY-------TIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATG 1451

  Fly   425 DKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKPGT 489
            ::...|:|:..|.:.|:.:.:.|:|.:||..::.:...:..|....|     ......:|:..|:
Human  1452 ERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTW-----TNLLVVVVELCGS 1511

  Fly   490 QLEAQDVVEYVRKRITAKFKQLNGGALIVDQ-IVRSGNR-KTNRSAVKEHFL 539
            :.||.|:|..|...:..:...:.|..::||. ::...:| :..|..:::.||
Human  1512 EQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFL 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	131/637 (21%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	124/610 (20%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	105/518 (20%)
		AFD_class_I	1012..1565	CDD:302604	121/601 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900