DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18586 and dip2ca

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_009295792.1	Gene:	dip2ca / 563890	ZFINID:	ZDB-GENE-031118-39	Length:	1618	Species:	Danio rerio

Alignment Length:	704	Identity:	133/704 - (18%)
Similarity:	247/704 - (35%)	Gaps:	216/704 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EVKQKLLNA--------MCTYDDKLKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQIS--- 58
            |.||..|..        ||.:.....:...|:.    .|.:....::.|::|:. |.|||.|
Zfish   949 ETKQLFLEGSLHPCNVLMCPHTCVTNLPKPRQK----QPEIGPASVMVGNLVSG-KRIAQASGRD 1008

  Fly    59 -------------------------ITEDIV--------------LTREDLHMNAMRVASYMRNM 84
                                     .|.|.|              ||...||..|.::|:.:...
Zfish  1009 LGQIEDNDQARKFLFLSEVLQWRAQTTPDHVLFTLLSSRGAVLSSLTCLQLHKRAEKIATMLMER 1073

  Fly    85 G-LGQTDIVGVMGRHTTHQSAVAYACFFNG------TPLHALHNAYEEACIAKLFGITKPRLIFC 142
            | |...|.|.::........|..|.|.:.|      .|.|..:.|.....:..:..:::...:..
Zfish  1074 GHLQDGDHVALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACVMT 1138

  Fly   143 DGDEYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRL-KDGIDHTLAIL---- 202
            .....:.:||......|.:   |..|       .||.|..:...:|.:| |.....|||.|
Zfish  1139 TQIISKLLKSKEASAAVDV---RTWP-------PVLDTDDLPKKKPPQLYKPSNPDTLAYLDFSV 1193

  Fly   203 -----------SSSGTSGFPKAVTI------SNSHKIIVD-YMAINNSNIQYTSSTLDWCSGLSM 249
                       |.:.||.|.:::.:      |....|.:| |..:         ..:.||   ..
Zfish  1194 STTGMLAGVKMSHTATSAFCRSIKLQCELYPSREVAICLDPYCGL---------GFVLWC---LC 1246

  Fly   250 AITSGVFSTTSIIADCDFDPGLFCRAIGKYRI-------SMVLLSSSYLAIFANCPEFESADLSS 307
            ::.||..|.....::.:.:|.|:..|:.::|:       |::.|.:..|.:.....:....|||.
Zfish  1247 SVYSGHQSILIPPSELEVNPALWLLAVSQFRVRDTFCSYSVMELCTKGLGLQTESLKARGLDLSR 1311

  Fly   308 LNYVIFGGSSCSLEVQRKVR-------SRLSHD------CLNFCYGLTELNSAGSVNLNFDEKPN 359
            :.       :|.:..:.:.|       |:|..|      .::..:|.       .|||....:|:
Zfish  1312 VR-------TCVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGC-------RVNLAICLQPH 1362

  Fly   360 SVG-------------------RAIRGIKIKVID----------EQG-------------EAQEP 382
            .:|                   ||:|..::::::          |.|             |.:.|
Zfish  1363 RLGKLADQGTSGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGP 1427

  Fly   383 ---NVVGEICFHNSQKWAGYYK-NPDETRQ---------IQDSEN-WIHTGDLGYV--------- 424
               :.:|||..|.:...:||:. ..||..|         ..|::. |..||.||::
Zfish  1428 LGDSHLGEIWVHCAHNGSGYFTVYGDEALQSDHFNSRLSFGDTQTVWARTGYLGFLRRTELTDAS 1492

  Fly   425 -DKDGYLFVIDRLKDMLKYQNIMYYPSEIE-NVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKP 487
             ::...|:|:..|.:.::.:.:.|:|.:|| :||....:::|..||. |     ......:|:..
Zfish  1493 GERHDALYVVGALDEAMELRGMRYHPIDIETSVIRTHKSIMECAVFP-W-----TNLLVVVVELE 1551

  Fly   488 GTQLEAQDVVEYVRKRITAKFKQLNGGALIVD-QIVRSGNR-KTNRSAVKEHFL 539
            |::.||.|:|..|...:..:...:.|..::|| .::...:| :..|..:::.||
Zfish  1552 GSEQEALDLVPLVTNAVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFL 1605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	126/666 (19%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	118/635 (19%)
dip2ca	XP_009295792.1	DMAP_binding	6..118	CDD:283995
		CaiC	369..960	CDD:223395	4/10 (40%)
		Dip2	393..957	CDD:213273	4/7 (57%)
		AMP-binding	1028..1512	CDD:278902	94/519 (18%)
		AFD_class_I	1047..1607	CDD:302604	115/601 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900