Protein Alignment CG18586 and ACSS2

DIOPT Version :9

• Sequence 1: NP_647993.2
• Gene: CG18586 / 38659
• FlyBaseID: FBgn0035642
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: XP_011527207.1
• Gene: ACSS2 / 55902
• HGNCID: 15814
• Length: 737
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 83/400 - (20%)
• Similarity: 145/400 - (36%)
• Gaps: 80/400 - (20%)

  Fly   199 LAILSSSGTSGFPKAVT---------ISNSHKIIVDYMAINNSNIQYTSSTLDWCSGLSMAITSG 254
            |.||.:||::|.||.|.         ::.:.|.:.|:.|   .::.:.::.:.|.:|.|. :|.|
Human   337 LFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHA---EDVFWCTADIGWITGHSY-VTYG 397

  Fly   255 VFS--TTSIIADCDF-------DPGLFCRAIGKYRISMVLLSSSYLAI---FANCP--EFESADL 305
            ..:  .||::    |       |.......:.||:::....:.:.:.:   |.:.|  :...|.|
Human   398 PLANGATSVL----FEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFGDEPVTKHSRASL 458

  Fly   306 SSLNYV--------------IFGGSSCSLEVQRKVRSRLSHDCLNFCYGLTELNSAGSVNLNFDE 356
            ..|..|              :.|...|.: |....::......|....|.|.:
Human   459 QVLGTVGEPINPEAWLWYHRVVGAQRCPI-VDTFWQTETGGHMLTPLPGATPM------------ 510

  Fly   357 KPNSVGRAIRGIKIKVIDEQGEAQEPNVVGEICFHNSQKWAGYYKNP--------------DETR 407
            ||.|......|:...:::|.||..|....|.:.......|...:|.|              .||.
Human   511 KPGSATFPFFGVAPAILNESGEELEGEAEGYLLLRTETSWLEVFKQPWPGIMRTVYGNHERFETT 575

  Fly   408 QIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGIWD 472
            ..:....:..|||....|:|||.::..|:.|||.....:...:|:|:.:.|...|.||.|.|...
Human   576 YFKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPH 640

  Fly   473 PVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQIVRS--GNRKTNRSAVK 535
            ||.| |.....|........:..:.|.::|:|..|.     |.:.....:::  |..||....:.
Human   641 PVKG-ECLYCFVTLCDGHTFSPKLTEELKKQIREKI-----GPIATPDYIQNAPGLPKTRSGKIM 699

  Fly   536 EHFLKNYNNN 545
            ...|:....|
Human   700 RRVLRKIAQN 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	82/394 (21%)
		AFD_class_I	55..530	CDD:302604	80/383 (21%)
ACSS2	XP_011527207.1	PRK00174	31..728	CDD:234677	82/399 (21%)
		ACS	51..721	CDD:213313	82/399 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.993157	Normalized mean entropy	S690
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860