DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and CG6300

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_650828.1	Gene:	CG6300 / 42351	FlyBaseID:	FBgn0038730	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	298/530 - (56%)
Similarity:	398/530 - (75%)	Gaps:	0/530 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TYDDKLKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQISITEDIVLTREDLHMNAMRVASY 80
            :||:..|||||......|.|:||||||||.:|..:|:|.||||.||..||||.:|..||||:|||
  Fly     8 SYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQLTAQISATEGTVLTRGELLANAMRLASY 72

  Fly    81 MRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDGD 145
            ||::||.|:||||::||:|||..||||||||||...|:|:..|:...|.|::.:|:|.:||||||
  Fly    73 MRSLGLLQSDIVGIIGRNTTHMLAVAYACFFNGIAFHSLNITYDRDTIEKIYKVTRPSIIFCDGD 137

  Fly   146 EYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLKDGIDHTLAILSSSGTSGF 210
            |:|||:|||.:|.|.||||||||..|::|.:|:.||:.:||||.:|:.|.|.|||||.||||:|.
  Fly   138 EFEKVRSATAELDVKIVTMRNHPLDSIKIDEVVATPIEENFQPAKLEKGNDQTLAILCSSGTTGT 202

  Fly   211 PKAVTISNSHKIIVDYMAINNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADCDFDPGLFCRA 275
            ||||||:||..|:.....:..:::||:.:||||.:||...|||||||||.||||..|||....|.
  Fly   203 PKAVTITNSRHILAGNYHLTTADVQYSHNTLDWITGLLTTITSGVFSTTRIIADNAFDPAFALRI 267

  Fly   276 IGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCYG 340
            |.:|:::..:...|.:|:..|||:||:.|:|||...:||||..:||||:.:|||||||||.|.||
  Fly   268 IEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYMFGGSRAALEVQKGIRSRLSHDCLQFVYG 332

  Fly   341 LTELNSAGSVNLNFDEKPNSVGRAIRGIKIKVIDEQGEAQEPNVVGEICFHNSQKWAGYYKNPDE 405
            .|||.:..::|.:||||..|||:.:.|:|:|:|::.||:..|:.:||:|..|:|.|:|||.|..|
  Fly   333 FTELGAMATINCHFDEKTGSVGQLVNGLKMKIINDDGESLGPDEIGEVCIMNNQHWSGYYGNEVE 397

  Fly   406 TRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGI 470
            ||.::||..|.|:|||||:|:||:|:::||.|:|||||||||||::||:||:|||.|.|.|||||
  Fly   398 TRNMRDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMYYPNDIESVISEMPQVAEVCVFGI 462

  Fly   471 WDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQIVRSGNRKTNRSAVK 535
            |..:.||||||::|||.|::|||||||:|||.|..:|:|||||||:|||.:.||.|.||||.|.|
  Fly   463 WSNIFGDEAAAAVVKKLGSELEAQDVVDYVRSRTDSKYKQLNGGAVIVDDLQRSANGKTNRMANK 527

  Fly   536 EHFLKNYNNN 545
            .:||...|.:
  Fly   528 AYFLHLKNRS 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	289/505 (57%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	270/474 (57%)
CG6300	NP_650828.1	CaiC	26..523	CDD:223395	283/496 (57%)
CG6300	NP_650828.1	AFD_class_I	47..522	CDD:302604	270/474 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471290
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I5187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	11	10.910