DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18586 and dip-2

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001293298.1	Gene:	dip-2 / 3565539	WormBaseID:	WBGene00017885	Length:	1681	Species:	Caenorhabditis elegans

Alignment Length:	558	Identity:	115/558 - (20%)
Similarity:	203/558 - (36%)	Gaps:	135/558 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LTREDLHMNAMRVASYM-------------RNMGLGQTDIVGVMGRHT--THQSAVAYACFFNG- 113
            ||...||..|.:|| ||             :|:.....|.|.::..:|  .|..|..|.|...|
Worm   441 LTYGKLHSRAGKVA-YMLLTKTVQVNKDGSKNVMCKPGDRVALIYPNTQPLHFLAAFYGCLQAGV 504

  Fly   114 --TPLHALHNAYEEACIAK---LFGITKPRLIFCDGDEY----EKVK--------SATKDLQVT- 160
              .|:. :.::..||.||:   |.|....::.......|    :||.        |.:..|..|
Worm   505 IPVPVE-MPSSKREAGIAQLGFLLGNCGVKVALTSESCYKGLPKKVNTSSTFSAPSGSNSLTGTS 568

  Fly   161 --IVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLKDGIDHTLAILS-SSGTSGFPKAVTISNSHKI 222
              ||..|..||....:.:.::.|......|.||   .|.|:|.:. ::|..|..|...::. ..:
Worm   569 SEIVDFRGWPRLWWAVTEHMSKPSRDWTAPPRL---ADETIAYIEYTTGNDGTVKGCCVTR-QAV 629

  Fly   223 IVDYMAINNSNIQYTSSTLDWC-------SGLSMAITSGVFSTTSII----ADCDFDPGLFCRAI 276
            .....|:..: ::|.......|       .||..||.:.:|:...:|    :....:|..:...:
Worm   630 FAHCRALTTA-MEYKEDETMVCVVDFKREVGLWHAILASIFNGMKVIFVPYSLMKMNPATWMHMV 693

  Fly   277 GKYRISMVLLSSSYL--AIFANCPEFESADLSSLNYVIFGG-------SSC-------------- 318
            .||:.:..|:.|..|  |:.|. .:.:...|:||..::...       |||
Worm   694 SKYQATTALVKSRDLHWALLAT-RDHKDISLASLRTLLVADGANPWSLSSCDAFAAAFTPSPYSL 757

  Fly   319 ---------------SLEVQRK---------VRSRLSHDCLNFCYGLTEL-NSAGSVNLNFDEKP 358
                           ::.::|:         .|..||...|:.|....:. ||..|:.|
Worm   758 RPDAMCPCAGSSETGTISIRRRGNAQLGSQSGRGILSMSALSHCVVRVDTENSLTSLTL------ 816

  Fly   359 NSVGRAIRG--IKIKVIDEQGEAQEPNVVGEICFHNSQKWAGYYKNPDETR------------QI 409
            ...|:.:.|  :.:..||......:.:.:||||...:.....|:....:|.            ::
Worm   817 QDAGQIVAGAVVVVTAIDGSNRLCQADEIGEICVSANSTAQLYWALDGQTHHTFKVEPVGEYGKL 881

  Fly   410 QDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSE--IENVIAEMPNVL----EACVF 468
            ..:..::.:|.:|::..||.:||:.|.:.:|.... .|:.::  |..|:|..|...    ..|||
Worm   882 IGAVRYVRSGLIGFMGPDGMVFVVARRQSLLAVSG-RYHSADDIIATVLAVEPMKFVYRGRICVF 945

  Fly   469 GIWDPVNGDEAAASLV-KKPG-TQLEAQDVVEYVRKRI 504
            .  ..|..||....:. :||. ::.||.|.:..|.:.|
Worm   946 S--TSVLRDERIVIVAEQKPNCSEEEAFDWITRVLRAI 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	115/558 (21%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	115/558 (21%)
dip-2	NP_001293298.1	DMAP_binding	4..114	CDD:368923
		Dip2	427..1027	CDD:341231	115/558 (21%)
		Dip2	1096..1677	CDD:341231
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900