DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and Acsm2

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_653349.1	Gene:	Acsm2 / 246263	RGDID:	708383	Length:	572	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	122/548 - (22%)
Similarity:	207/548 - (37%)	Gaps:	105/548 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 WSGREAPSLFSPNLSIGEIIFGDMVNN-------------PKLIAQISITEDIVLTREDLHMNAM 75
            |..:|.|:.|:        ...|::::             |.|.......|::.....:|...:.
  Rat    35 WGHQEVPAKFN--------FASDVIDHWASLEKAGKRSPGPALWWMNGSGEELKWNFRELSEISK 91

  Fly    76 RVASYMRN-MGLGQTDIVGVMGRHTTHQSAVAYAC------FFNGTP-------LHALHNAYEEA 126
            :.|:.:.. .||.:.|.|.|:.........|...|      |..||.       |:.|.::...|
  Rat    92 QTANVLTGACGLQRGDRVAVVLPRVPEWWLVTLGCMRSGLVFMPGTTQMKSTDILYRLQSSKARA 156

  Fly   127 CIAKLFGITKPRLIFCDGDE-YEKVKSATKD---LQVTIVTMRNHPRGSVRIQDVL--TTPVMQN 185
            .:|              ||| .::|.:...|   |::.::....:..|.:..:.:|  .:|:.|.
  Rat   157 IVA--------------GDEVVQEVDAVAPDCSFLKIKLLVSEKNREGWLNFKALLKDASPIHQC 207

  Fly   186 FQPLRLKDGIDHTLAILSSSGTSGFPKAVTISNSH-------KIIVDYMAINNSNIQYTSSTLDW 243
            .:.:.     ..:.||..:|||||.||..  .:||       |:...:..:..|:..:|.|...|
  Rat   208 VETVS-----QESAAIYFTSGTSGPPKMA--EHSHCSLGLKAKMDAGWTGLGPSDTMWTISDTGW 265

  Fly   244 CSGLSMAITSGVFSTTSIIADC-------DFDPGLFCRAIGKYRISMVLLSSSYLAIFANCPEFE 301
            ...:     .|.|....::..|       .|||....:.:..|.|:.:|.:.....:..
  Rat   266 ILNI-----LGSFLEPWVLGTCIFVHLLPKFDPQTVLKVLSSYPINTLLGAPLIYRMLL------ 319

  Fly   302 SADLSS-----LNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCYGLTELNSAGSVNLNFDEKPNSV 361
            ..||||     |:....||.:...|.....:::...: :...||.||......|:.....||..:
  Rat   320 QQDLSSYKFPHLHSCFSGGETLLPETLESWKAKTGLE-IREIYGQTETGITCRVSRTMKVKPGYL 383

  Fly   362 GRAIRGIKIKVIDEQGEAQEPNVVGEICFHNSQ-----KWAGYYKNPDETRQIQDSENWIHTGDL 421
            |.||....::||||||....|...|::......     .::||..||.:|:.....:.|: .||.
  Rat   384 GTAIVPYDVQVIDEQGNVLPPGKEGDMALRVKPIRPIGMFSGYVDNPKKTQANIRGDFWL-LGDR 447

  Fly   422 GYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGIWDPVNGDEAAASLVKK 486
            |..|.:||...:.|..|::........|||:||.:.|.|.|:|..|....||:..:...|.:|..
  Rat   448 GIKDTEGYFHFMGRTDDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPIRREVVKAFVVLA 512

  Fly   487 PGTQLEAQD-----VVEYVRKRITAKFK 509
            |......||     :.|:| |.:||.:|
  Rat   513 PEFLSHDQDQLTKVLQEHV-KSVTAPYK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	118/537 (22%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	115/504 (23%)
Acsm2	NP_653349.1	AFD_class_I	40..568	CDD:302604	120/543 (22%)
		Acs	40..565	CDD:223442	120/543 (22%)
		Coenzyme A binding. /evidence=ECO:0000250	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000250	540..542		122/548 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010