Protein Alignment CG18586 and ACSL3

DIOPT Version :10

• Sequence 1: NP_647993.2
• Gene: CG18586 / 38659
• FlyBaseID: FBgn0035642
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: NP_004448.2
• Gene: ACSL3 / 2181
• HGNCID: 3570
• Length: 720
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 120/558 - (21%)
• Similarity: 196/558 - (35%)
• Gaps: 156/558 - (27%)

  Fly    50 NPKLIAQISITEDIVLTREDLHMNAMRVASYMRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGT 114
            |.|:..::.:.:...|:.||:.:.|....:.::.:|......:.:...........|.|||....
Human   120 NGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNF 184

  Fly   115 PLHALHNAYEEACIAKLFGITKPRLIFCDGDEYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVLT 179
            .|..|:.......|......|:...|.   ...|.:::..||: |::|.         |::.::|
Human   185 QLVTLYATLGGPAIVHALNETEVTNII---TSKELLQTKLKDI-VSLVP---------RLRHIIT 236

  Fly   180 T----PVMQNFQPLRLKDGIDHTLA--------------------------ILSSSGTSGFPKAV 214
            .    |....|.    |..|.||:|                          |:.:||::|.||.|
Human   237 VDGKPPTWSEFP----KGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGV 297

  Fly   215 TISNSH------------------KIIVDYMAI--------------NNSNIQYTS-STLDWCSG 246
            .||:|:                  .:.:.|:.:              :...|.|:| .||   :.
Human   298 MISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTL---AD 359

  Fly   247 LSMAITSGVFSTTSIIAD------------------------CDFDPGLFCRAIGKYRISMVLLS 287
            .|..|..|....||::..                        ..|...||..|   |...|..:|
Human   360 QSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILA---YNYKMEQIS 421

  Fly   288 SSYLAIFAN---CPEFESADLSSL-----NYVIFGGSSCSLEVQRKVRSRLSHDCLNFC------ 338
            ..     .|   |..|....:.||     ..::.||:..|...||         .:|.|
Human   422 KG-----RNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQR---------FMNICFCCPVG 472

  Fly   339 --YGLTELNSAGSVNLNFDEKPNSVGRAI--RGIKIKVIDEQG--EAQEPNVVGEICFHNSQKWA 397
              |||||...||:::..:|.....||..:  ..||:|..:|.|  ...:|:..|||.........
Human   473 QGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTM 537

  Fly   398 GYYKNPDETR----QIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYP-SEIENVIA 457
            |||||..:|:    :.::.:.|:.|||:|..:.||.|.:|||.||::|.|...|.. .::|..:.
Human   538 GYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALK 602

  Fly   458 EMPNVLEACVFG-------IWDPVNGDEAAASLVKKPG 488
            .:|.|...|.:.       |...|...:....|.:|.|
Human   603 NLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKG 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	Firefly_Luc_like	55..530	CDD:341237	118/553 (21%)
ACSL3	NP_004448.2	Adenylate forming domain, Class I superfamily	30..717	CDD:473059	120/558 (22%)