DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18586 and acs-9

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_510728.2	Gene:	acs-9 / 188659	WormBaseID:	WBGene00020634	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	533	Identity:	130/533 - (24%)
Similarity:	221/533 - (41%)	Gaps:	88/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EIIFGDMV--NNPKL-IAQISITEDIVLTREDLHMNAMRVASYMRNMGLGQTDIVGVMGRHTTHQ 102
            |.:|.|::  |..|. |.|..:.::.|:|.|::.....::...:..:|:.|.|.:.|...::...
Worm     7 ETLFHDLILENVVKFGIRQALVHDNQVITFEEIPQLVSKLVYKLLELGISQGDTILVCLPNSIWY 71

  Fly   103 SAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDGDEYEKVKSATKDLQVTIVTMRNH 167
            ..:..:|...|..|..:.:......|......:..:|:|.:    ||            |:..|:
Worm    72 PLLFLSCAKIGAVLSGISHESTAGEIKYSLKQSGAKLVFTN----EK------------VSKENY 120

  Fly   168 PRGSVRIQDVLTTPVM---------QNFQPLRLKDGIDHTLAILSSSGTSGFPKAVTISNSH--- 220
            ...|....:||...|.         ::|:|..|  .||..|....||||:|.||...:::.:
Worm   121 WALSENSVEVLPDSVKTYIDRITGHEDFRPENL--DIDSILLAPFSSGTTGAPKCCLLTHRNFLA 183

  Fly   221 ------KIIVDYMAINNSNIQYTSSTLDWCSG---LSMAITSGVFSTTSIIADCDFDPGLFCRAI 276
                  |.:.|.:...:|............||   |.:.:..|  .||.|::  :|.|.:....|
Worm   184 ATYSLKKFLFDQLLAQSSMKTLAFLPFHHASGFWALLICLLEG--CTTYIMS--EFHPIVMMDLI 244

  Fly   277 GKYRISMVLLSSSYLAIF-------ANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRS---RLS 331
            .||.|..:.:......||       ..||        ||..::.|.|....:..:::.|   :::
Worm   245 EKYEIDTINIVPPIANIFLKMGILQGRCP--------SLRTILCGSSGLQKDRCKRLLSIFPQVT 301

  Fly   332 HDCLNFCYGLTELNSAGSVNLNFD---EKPNSVGRAIRGIKIKVIDE-QGEAQEPNVVGEICFHN 392
            |....  ||:|||.....|. .||   |...|.|..:.|.:.|:.:. .||.:        .:..
Worm   302 HFIQG--YGMTELVVLSCVT-PFDDNFEHLGSCGHILPGFETKLFEHPTGETE--------LWLK 355

  Fly   393 SQKWAGYYKN--PDETRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENV 455
            |......|||  |:     .|.::|:||||: ..:|.|:.:|:||:||::|.......|:|||||
Worm   356 SDAIMKAYKNGTPN-----LDEDDWLHTGDI-VTEKGGFFYVVDRMKDLIKLNGYQVSPTEIENV 414

  Fly   456 IAEMPNVLEACVFGIWDPVNGDEAAASLV-KKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVD 519
            |..:|.|.|..|.||.|.:.|....|.:| :|...:|.....:|:..|...:..|||.||..|:.
Worm   415 ILTLPKVAEVAVVGIEDELCGQLPKAYIVLEKNADELLFLKHLEHTMKEKLSAVKQLRGGVSIIK 479

  Fly   520 QIVRSGNRKTNRS 532
            ::.:|.:.|..::
Worm   480 EMPKSSSGKIQKN 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	130/533 (24%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	124/512 (24%)
acs-9	NP_510728.2	CaiC	1..494	CDD:223395	130/533 (24%)
acs-9	NP_510728.2	Firefly_Luc_like	26..490	CDD:213279	123/510 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880