DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18586 and Acsl4

DIOPT Version :9

Sequence 1:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_006257376.1	Gene:	Acsl4 / 113976	RGDID:	69401	Length:	711	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	135/615 - (21%)
Similarity:	222/615 - (36%)	Gaps:	182/615 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 MNAMRVASYMRNMGLGQTDIVGVMGRHT--------THQSAVAYACFFNGTPLHALHNAY-EEAC 127
            :|.:.|...:.|.|.|.| .:|:..::|        ......|..||....||..|:... :||.
  Rat   126 INYLEVNCRVNNFGSGLT-ALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGKEAV 189

  Fly   128 IAKL------FGITKPRLIFCDGDEYEKVKSATKDLQVT--IVTMRN-------HPRG----SVR 173
            :..|      :.||...|:      ..|:|:|..|:...  |:.:.|       :|.|    |::
  Rat   190 VHGLNESEASYLITSVELL------ESKLKAALLDINCVKHIIYVDNKTINRAEYPEGLEIHSMQ 248

  Fly   174 -IQDVLTTPVMQNFQPLRLKDGIDHTLAILSSSGTSGFPKAVTISNSHKII--------VDYMAI 229
             ::::.:.|...:..|.|.... |..: ::.:||::|.||.|.:.:|:.|.        :..:..
  Rat   249 SVEELGSKPENSSIPPSRPTPS-DMAI-VMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGP 311

  Fly   230 NNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADCDFDPGLFCRAIGKYRISMVLLSSSYL--- 291
            .::.|.|          |.:|   .|...|:.|: | |..|  || || |...:.|...|..
  Rat   312 KDTYIGY----------LPLA---HVLELTAEIS-C-FTYG--CR-IG-YSSPLTLSDQSSKIKK 357

  Fly   292 -----------AIFANCPEFES-------ADLSSLNYVI------------------FGGSSCSL 320
                       .:.|..||...       :.:..:||:.                  :....|:|
  Rat   358 GSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYIQKTLFKIGYDYKLEQIKKGYDAPLCNL 422

  Fly   321 EVQRKVRSRL-----------------SHDCLNFC--------YGLTELNSAGSVNLNFDEKPNS 360
            .:.:||::.|                 :|..:|.|        |||||...||:|....|.....
  Rat   423 ILFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGR 487

  Fly   361 VGRAIRGIKIKVIDEQGEA----QEPNVVGEICFHNSQKWAGYYKNPDETRQ----IQDSENWIH 417
            ||..:...:||:.|.|...    .:||..|||.........||:||.::|.:    .::.:.|..
  Rat   488 VGAPLICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYSVDENGQRWFC 552

  Fly   418 TGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYP-SEIENVIAEMPNVLEACVF------------- 468
            |||:|....||.|.:|||.||::|.|...|.. .::|..:...|.:...|.|
  Rat   553 TGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVV 617

  Fly   469 ----------------GIW-DPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFK-----QL 511
                            |.| |..|.....|.::|:   ..||.:.::..|..|..|.:     ..
  Rat   618 PNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKE---IREAANAMKLERFEIPIKVRLSPEPWT 679

  Fly   512 NGGALIVDQIVRSGNRKTNRSAVKEHFLKN 541
            ....|:.|..      |..|..:|.|:||:
  Rat   680 PETGLVTDAF------KLKRKELKNHYLKD 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	134/613 (22%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	130/602 (22%)
Acsl4	XP_006257376.1	LC_FACS_euk1	121..696	CDD:341294	131/606 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930